Results 281 to 290 of about 323,586 (342)

Beta-2-glycoprotein I antibodies in patients with thrombosis

Scandinavian Journal of Clinical and Laboratory Investigation, 2003
The laboratory diagnosis of antiphospholipid antibody syndrome currently requires two consecutive positive results in either lupus anticoagulant or anticardiolipin antibody assays. Antibodies against beta-2-glycoprotein I (abeta2-GPI) are suggested as a new marker for the syndrome.
F, Ebeling, T, Pettersson, L, Muukkonen, E, Vahtera, V, Rasi   +4 more
openaire   +2 more sources

Beta-2-glycoprotein I Dependent Lupus Anticoagulants Form Stable Bivalent Antibody Beta-2-Glycoprotein I Complexes on Phospholipid Surfaces

Thrombosis and Haemostasis, 1998
SummaryThe precise mechanism by which Beta-2-glycoprotein I (β2GPI-) dependent lupus anticoagulants lengthen phospholipid-dependent clotting reactions is still poorly understood. In order to study this, murine monoclonal antibodies (moabs) against human β2GPI were raised. Eight of the 21 anti-β2GPI moabs, obtained from 2 fusions, fulfilled the criteria
J, Arnout, C, Wittevrongel, M, Vanrusselt, M, Hoylaerts, J, Vermylen   +4 more
openaire   +2 more sources

B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinemia-aggravated abdominal aortic aneurysm.

Cardiovascular Research, 2019
AIMS Overactivated B cells secrete pathological antibodies, which in turn accelerate the formation of abdominal aortic aneurysms (AAAs). Hyperhomocysteinemia (HHcy) aggravates AAA in mice; however, the underlying mechanisms remain largely elusive.
Fangyu Shao, Yutong Miao, Yan Zhang, Lulu Han, Xiaolong Ma, Jiacheng Deng, Changtao Jiang, W. Kong, Qingbo Xu, Juan Feng, Xian Wang   +10 more
semanticscholar   +1 more source

Beta 2 glycoprotein I-function in health and disease

Thrombosis Research, 2004
Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS). It is abundant in human plasma and shares high homology between different mammalian species. Although the exact physiological function of beta2GPI has not been fully elucidated, several interactions have been described with other proteins ...
Spiros, Miyakis, Bill, Giannakopoulos, Steven A, Krilis   +2 more
openaire   +2 more sources

Correlation between beta-2-glycoprotein I gene polymorphism and anti-beta-2 glycoprotein I antibodies in patients with multibacillary leprosy

Archives of Dermatological Research, 2010
Antiphospholipid antibodies, such as anti-beta2-glycoprotein I (beta2GPI), are present in multibacillary leprosy (MB) patients; however, MB patients do not usually present with antiphospholipid antibody syndrome (APS), which is characterized by thromboembolic phenomena (TEP).
Maria José Franco, Brochado, José Fernando C, Figueiredo, Celso Teixeira, Mendes-Junior, Paulo, Louzada-Junior, Olivia Makiyama, Kim, Ana Maria, Roselino   +5 more
openaire   +2 more sources

[Antiphospholipid and anti beta 2-glycoprotein I antibodies].

Annales de biologie clinique, 1995
Recent studies have shown that beta 2glycoprotein I (beta 2GPI), a plasma inhibitor of coagulation with affinity for anionic phospholipids, is frequently required for the formation of the epitopes recognized by some anti-phospholipid antibodies.
J, Arvieux, B, Roussel, M G, Colomb
openaire   +2 more sources

Beta-2-glycoprotein-I, infections, antiphospholipid syndrome and therapeutic considerations

Clinical Immunology, 2004
Evidence supports the association between infectious agents, antiphospholipid syndrome (APS), and the presence of antiphospholipid antibodies and anti-beta2-glycoprotein-I (beta2GPI) antibodies. Several mechanisms have been proposed to explain the role of bacteria/viruses in induction of an autoimmune condition, such as molecular mimicry between ...
Miri, Blank, Yehuda, Shoenfeld
openaire   +2 more sources

Anti-β 2 -Glycoprotein I Autoantibodies and Atherosclerosis

International Reviews of Immunology, 2002
beta 2-Glycoprotein I (beta 2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). We previously reported that beta 2-GPI specifically binds to oxidized low-density lipoprotein (oxLDL).
Eiji, Matsuura, Kazuko, Kobayashi, Junko, Kasahara, Tatsuji, Yasuda, Hirofumi, Makino, Takao, Koike, Yehuda, Shoenfeld   +6 more
openaire   +2 more sources

beta 2-Glycoprotein I and anti-beta 2-glycoprotein I antibodies: where are we now?

British journal of rheumatology, 1998
beta 2-Glycoprotein I (beta 2-GPI), a plasma protein with in vitro anticoagulant properties, has been recognized to have an important role in the antiphospholipid syndrome (APS) as a cofactor and an (co)antigen in ELISA assays. Although beta 2-GPI levels were found to be increased in some patients with APS, the clinical value of measuring beta 2-GPI ...
M, Inanç, E L, Radway-Bright, D A, Isenberg   +2 more
openaire   +1 more source

Anticardiolipin Antibody and Anti-beta 2 Glycoprotein I Antibody Assays

2013
Antiphospholipid syndrome (APS) is an autoimmune disease and is a risk factor for a number of clinical manifestations; the classic presentations include fetal death or thrombosis (arterial or venous thromboembolism), in the presence of persistently increased titers of antiphospholipid (aPL) antibodies.
Anne, Raby, Karen, Moffat, Mark, Crowther   +2 more
openaire   +2 more sources