Results 281 to 290 of about 384,078 (314)

Beta 2 glycoprotein I is a substrate of thiol oxidoreductases [PDF]

Blood, 2010
To the editor: Beta 2 glycoprotein I (β2GPI) is an abundant plasma protein recognized as the major autoantigen in the antiphospholipid syndrome. Although the crystal structure of β2GPI has been resolved,[1][1],[2][2] its normal function remains unknown.
Gemmell, Rosalie, Passam, Freda H., Rahgozar, Soheila, Qi, Miao, Raftery, Mark J., Wong, Jason W.H., Tanaka, Kumiko, Ioannou, Yiannis, Zhang, Jing Yun, Qi, Jian Chen, Giannakopoulos, Bill, Hughes, Will E., Hogg, Philip J., Krilis, Steven A.   +13 more
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Beta-2-glycoprotein I antibodies in patients with thrombosis

Scandinavian Journal of Clinical and Laboratory Investigation, 2003
The laboratory diagnosis of antiphospholipid antibody syndrome currently requires two consecutive positive results in either lupus anticoagulant or anticardiolipin antibody assays. Antibodies against beta-2-glycoprotein I (abeta2-GPI) are suggested as a new marker for the syndrome.
L. Muukkonen, T. Pettersson, Freja Ebeling, Elina Vahtera, Vesa Rasi   +4 more
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Beta 2 glycoprotein I-function in health and disease

Thrombosis Research, 2004
Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS). It is abundant in human plasma and shares high homology between different mammalian species. Although the exact physiological function of beta2GPI has not been fully elucidated, several interactions have been described with other proteins ...
Steven A. Krilis, Bill Giannakopoulos, Spiros Miyakis   +2 more
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Avidity of anti-beta-2-glycoprotein I antibodies

Autoimmunity Reviews, 2005
The terms affinity and avidity are often used indiscriminately, despite clearly differing. Since affinity refers to monovalent binding of antibodies to a monovalent epitope, the majority of data on the binding of anti-beta2-glycoprotein I antibodies (anti-beta2-GPI) characterized their avidity rather than affinity.
Borut Božič, Borut Božič, Blaž Rozman, Tanja Kveder, Saša Čučnik   +4 more
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B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinemia-aggravated abdominal aortic aneurysm.

Cardiovascular Research, 2019
AIMS Overactivated B cells secrete pathological antibodies, which in turn accelerate the formation of abdominal aortic aneurysms (AAAs). Hyperhomocysteinemia (HHcy) aggravates AAA in mice; however, the underlying mechanisms remain largely elusive.
Fangyu Shao, Yutong Miao, Yan Zhang, Lulu Han, Xiaolong Ma, Jiacheng Deng, Changtao Jiang, W. Kong, Qingbo Xu, Juan Feng, Xian Wang   +10 more
semanticscholar   +1 more source

Correlation between beta-2-glycoprotein I gene polymorphism and anti-beta-2 glycoprotein I antibodies in patients with multibacillary leprosy

Archives of Dermatological Research, 2010
Antiphospholipid antibodies, such as anti-beta2-glycoprotein I (beta2GPI), are present in multibacillary leprosy (MB) patients; however, MB patients do not usually present with antiphospholipid antibody syndrome (APS), which is characterized by thromboembolic phenomena (TEP).
Olivia Makiyama Kim, Paulo Louzada-Junior, José Fernando de Castro Figueiredo, Maria José Franco Brochado, Celso T. Mendes-Junior, Ana Maria Ferreira Roselino   +5 more
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Beta-2-glycoprotein I Dependent Lupus Anticoagulants Form Stable Bivalent Antibody Beta-2-Glycoprotein I Complexes on Phospholipid Surfaces

Thrombosis and Haemostasis, 1998
SummaryThe precise mechanism by which Beta-2-glycoprotein I (β2GPI-) dependent lupus anticoagulants lengthen phospholipid-dependent clotting reactions is still poorly understood. In order to study this, murine monoclonal antibodies (moabs) against human β2GPI were raised. Eight of the 21 anti-β2GPI moabs, obtained from 2 fusions, fulfilled the criteria
M Vanrusselt, Christine Wittevrongel, Jozef Vermylen, Marc Hoylaerts, Jozef Arnout   +4 more
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Anti-β 2 -Glycoprotein I Autoantibodies and Atherosclerosis

International Reviews of Immunology, 2002
beta 2-Glycoprotein I (beta 2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). We previously reported that beta 2-GPI specifically binds to oxidized low-density lipoprotein (oxLDL).
Junko Kasahara, Hirofumi Makino, Yehuda Shoenfeld, Eiji Matsuura, Tatsuji Yasuda, Kazuko Kobayashi, Takao Koike   +6 more
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Evaluation of three fully automated immunoassay systems for detection of IgA anti‐beta 2‐glycoprotein I antibodies

International Journal of Laboratory Hematology, 2016
In recent years, we have been witnessing increased clinical interest in the determination of IgA anti‐beta 2‐glycoprotein I (aB2GPI) antibodies as well as increased demand for this test.
D. Pérez, J. A. Martínez-Flores, M. Serrano, D. Lora, E. Paz-Artal, J. Morales, A. Serrano   +6 more
semanticscholar   +1 more source

Consensus guidelines on anti-beta 2 glycoprotein I testing and reporting

Pathology, 2008
Consensus guidelines on anti-beta 2 glycoprotein I (anti-beta2GPI) testing have been developed to help minimise laboratory variation in the performance and reporting of assays for these antibodies. These guidelines include minimum and optional recommendations for the following aspects of anti-beta2GPI testing and reporting: (1) isotype of anti-beta2GPI
David Gillis, Richard C. W. Wong, R. Laurent, Wendy Pollock, R.J. Wilson, Timothy A. Brighton, Marianne Empson, Emmanuel J. Favaloro, Michelle J. Hendle, D. Mallon, Stephen Adelstein, Stewart M. Smith, Karl W. Baumgart, Richard Steele, Robert Bird   +14 more
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