Results 291 to 300 of about 323,586 (342)

Anti-beta 2-glycoprotein I autoantibodies from patients with the "antiphospholipid" syndrome bind to beta 2-glycoprotein I with low affinity: dimerization of beta 2-glycoprotein I induces a significant increase in anti-beta 2-glycoprotein I antibody affinity.

Journal of immunology (Baltimore, Md. : 1950), 1998
"Antiphospholipid" autoantibodies are associated with arterial and venous thrombosis, recurrent fetal loss, and thrombocytopenia. At present, the best-characterized antigenic target for these autoantibodies (or Abs) is the phospholipid-binding protein beta2-glycoprotein I (beta2GPI).
Y, Sheng, D A, Kandiah, S A, Krilis
openaire   +1 more source

Consensus guidelines on anti-beta 2 glycoprotein I testing and reporting

Pathology, 2008
Consensus guidelines on anti-beta 2 glycoprotein I (anti-beta2GPI) testing have been developed to help minimise laboratory variation in the performance and reporting of assays for these antibodies. These guidelines include minimum and optional recommendations for the following aspects of anti-beta2GPI testing and reporting: (1) isotype of anti-beta2GPI
R C W, Wong, E J, Favaloro, S, Adelstein, K, Baumgart, R, Bird, T A, Brighton, M, Empson, D, Gillis, M J, Hendle, R, Laurent, D, Mallon, W, Pollock, S, Smith, R H, Steele, R J, Wilson   +14 more
openaire   +2 more sources

Beta 2-glycoprotein I--a Bi-Allelic polymorphism.

Acta anthropogenetica, 1981
Population samples from Hungary and India have been typed for beta 2-glycoprotein I concentrations. Whereas the Hungarian sample is in fairly good accord with the genetic model set up by Cleve2-beta 2-glycoprotein I concentrations are controlled by two autosomal codominant alleles BgN and BgD-the Indian samples do not fit this model.
H, Walter, R, Schliwa, H, Lankenau, I P, Singh, M K, Bhasin, P, Veerraju, J D, Goud, J, Nemeskeri   +7 more
openaire   +1 more source

Synchronized inhibition of the phospholipid mediated autoactivation of factor XII in plasma by beta 2-glycoprotein I and anti-beta 2-glycoprotein I.

Thrombosis and haemostasis, 1995
Lupus anticoagulants are a group of antibodies commonly found in patients with autoimmune diseases such as systemic lupus erythematosus. Lupus anticoagulants inhibit phospholipid dependent coagulation and may bind to negatively charged phospholipids.
I, Schousboe, M S, Rasmussen
openaire   +2 more sources

New Tests to Detect Antiphospholipid Antibodies: Anti-Domain I Beta-2-Glycoprotein-I Antibodies

Current Rheumatology Reports, 2014
Beta-2 glycoprotein I (β2GPI) is the main antigenic target for antiphospholipid antibodies (aPL), the serological markers of antiphospholipid syndrome (APS). Domain I (DI) of β2GPI has lately been identified as the main epitope targeted by antibodies reacting against β2GPI. DI is a cryptic epitope, becoming available for autoantibody binding when β2GPI
C.B. Chighizola, M. Gerosa, P.L. Meroni
openaire   +3 more sources

Anti-beta(2)-glycoprotein I antibody-mediated inhibition of activated protein C requires binding of beta(2)-glycoprotein I to phospholipids.

Thrombosis and haemostasis, 2003
To clarify the role(s) of anti-beta(2) GPI antibodies on thrombosis in anti-phospholipid antibody syndromes (APS), the effect of IgG from three patients on activated protein C (APC) was investigated using phospholipid vesicles and purified proteins. Two of the total IgG inhibited APC activity in the presence of beta(2)GPI, whereas the third IgG did not.
Tomonori, Izumi, Mary L, Pound, Zuowei, Su, G Michael, Iverson, Thomas L, Ortel   +4 more
openaire   +1 more source

Clinical significance of anti-beta 2-glycoprotein I antibodies.

Annales de medecine interne, 1997
Antiphospholipid antibodies are a heterogeneous group of autoantibodies with clinical importance because of their strong association with thrombotic events. Recent evidence have shown that antiphospholipid antibodies are not directed against phospholipids, as has previously been thought, but are a part of a large family of autoantibodies against ...
O, Amengual, T, Atsumi, M A, Khamashta, G R, Hughes   +3 more
openaire   +1 more source

Beta2-Glycoprotein I

Lupus, 1994
D A, Kandiah, S A, Krilis
openaire   +2 more sources

Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk.

Journal of Autoimmunity, 2021
M. Krilis, M. Qi, Y. Ioannou, J.Y. Zhang, Z. Ahmadi, J. Wong, P. Vlachoyiannopoulos, H. Moutsopoulos, T. Koike, A. Sturgess, B. Chong, S. Krilis, B. Giannakopoulos   +12 more
semanticscholar   +1 more source

Apolipoprotein H (beta-2-glycoprotein I) polymorphism in Asians.

Human biology, 1992
Apolipoprotein H (APOH) (beta-2-glycoprotein I) polymorphism has been studied in 1159 Asians. The sample included 872 Chinese, 179 Asiatic Indians (Dravidian), 91 Filipinos, and 17 Malays. APOH polymorphism was determined by isoelectric focusing of sera in thin-layer polyacrylamide gels containing 3 M urea followed by immunoblotting. The frequencies of
Saha, N., Kamboh, M.I., Kelly, L.J., Ferrell, R.E., Tay, J.S.   +4 more
openaire   +1 more source