Results 61 to 70 of about 384,078 (314)

Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif

BMC Genomic Data, 2023
Background The key evolutionary step leading to the pandemic virus was the acquisition of the PRRA furin cleavage motif at the spike glycoprotein S1/S2 junction by a progenitor of SARS-CoV-2.
Antonio R. Romeu
doaj   +1 more source

Comparative Binding Ability of Human Monoclonal Antibodies against Omicron Variants of SARS-CoV-2: An In Silico Investigation

Antibodies, 2023
Mutation(s) in the spike protein is the major characteristic trait of newly emerged SARS-CoV-2 variants such as Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Delta-plus.
Nabarun Chandra Das, Pritha Chakraborty, Jagadeesh Bayry, Suprabhat Mukherjee   +3 more
doaj   +1 more source

Characterization of binding of human β2-glycoprotein I to cardiolipin [PDF]

Biochemical Journal, 1995
beta 2-Glycoprotein I-cardiolipin complexes are reported to be a target antigen for the binding of a subset of anti-phospholipid antibodies. The characteristics of binding of beta 2-glycoprotein I to cardiolipin are reported in this paper. Binding at neutral pH is specific, saturable, dependent on ionic strength and independent of bivalent cation ...
H. Haupt, Z. Kertesz, Z. Kertesz, Alexander Steinkasserer, Adam M. Benham, Robert B. Sim, Bing-Bin Yu   +6 more
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Fluctuation in the Levels of Immunoglobulin M and Immunoglobulin G Antibodies for Cardiolipin and β2-Glycoprotein among Healthy Pregnant Women

Sultan Qaboos University Medical Journal, 2014
Objectives: Antiphospholipid antibodies fluctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy ...
Mohammed S. Al-Balushi, Sidgi S. Hasson, Elias A. Said, Juma Z. Al-Busaidi, Muna S. Al-Daihani, Mohammed S. Othman, Talal A. Sallam, Mohammed A. Idris, Moza Al-Kalbani, Nicholas Woodhouse, Ali A. Al-Jabri   +10 more
doaj   +2 more sources

Case Report: Optic neuritis as the initial presentation of Orientia tsutsugamushi infection detected by metagenomic next-generation sequencing

Frontiers in Immunology, 2023
Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi infection, and typically manifested as fever, eschar, lymphadenopathy, rash, and other flu-like signs.
Chuan-bin Sun, Zhiqiong Ma, Zhe Liu
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Existence and regularity of optimal shapes for spectral functionals with Robin boundary conditions [PDF]

arXiv, 2021
We establish the existence and find some qualitative properties of open sets that minimize functionals of the form $ F(\lambda_1(\Omega;\beta),\dots,\lambda_k(\Omega;\beta))$ under measure constraint on $\Omega$, where $\lambda_i(\Omega;\beta)$ designates the $i$-th eigenvalue of the Laplace operator on $\Omega$ with Robin boundary conditions of ...
arxiv  

Evaluation of some non-elementary integrals involving sine, cosine, exponential and logarithmic integrals: Part I [PDF]

Ural Mathematical Journal 4(1) 2018, 24 - 42, 2017
The non-elementary integrals $\text{Si}_{\beta,\alpha}=\int [\sin{(\lambda x^\beta)}/(\lambda x^\alpha)] dx,\beta\ge1,\alpha\le\beta+1$ and $\text{Ci}_{\beta,\alpha}=\int [\cos{(\lambda x^\beta)}/(\lambda x^\alpha)] dx, \beta\ge1, \alpha\le2\beta+1$, where $\{\beta,\alpha\}\in\mathbb{R}$, are evaluated in terms of the hypergeometric functions $_{1}F_2$
arxiv   +1 more source