Results 291 to 300 of about 163,717 (335)
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British Journal of Dermatology, 2001
beta-catenin functions in signal transduction in the Wnt signalling pathway, which has recently been implicated in hair follicle (HF) morphogenesis. beta-catenin gene mutations affecting exon 3 have been reported in a high percentage of human pilomatrixomas.
G, Moreno-Bueno +4 more
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beta-catenin functions in signal transduction in the Wnt signalling pathway, which has recently been implicated in hair follicle (HF) morphogenesis. beta-catenin gene mutations affecting exon 3 have been reported in a high percentage of human pilomatrixomas.
G, Moreno-Bueno +4 more
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Wnt/beta-Catenin Signaling in Glioma
Journal of Neuroimmune Pharmacology, 2012Extensive data have shown that Wnt/beta-catenin signaling is associated with various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of Wnt/beta-catenin signaling in glioma, with particular focus on the expression signatures of the main components in Wnt/beta-catenin signaling, the role of key factors ...
Kailiang, Zhang +4 more
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p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction
European Journal of Neuroscience, 2001The neuronal cyclin-dependent kinase p35/cdk5 comprises a catalytic subunit (cdk5) and an activator subunit (p35). To identify novel p35/cdk5 substrates, we utilized the yeast two-hybrid system to screen for human p35 binding partners. From one such screen, we identified beta-catenin as an interacting protein.
Kesavapany, S +7 more
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Cytokine & growth factor reviews, 2000
The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes.
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The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes.
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HIF-2alpha enhances beta-catenin/TCF-driven transcription by interacting with beta-catenin.
Cancer research, 2011The tumor-promoting factors β-catenin and hypoxia-inducible factor (HIF) are often found to be coactivated in rapidly growing tumors. Recently, it was shown that HIF-1α negatively regulates Wnt/β-catenin signaling by sequestering β-catenin from β-catenin/T-cell factor (TCF).
Hyunsung, Choi +3 more
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Science's STKE : signal transduction knowledge environment, 2006
Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can modulate cell proliferation, survival, cell behavior, and cell fate in both embryos and adults.
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Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can modulate cell proliferation, survival, cell behavior, and cell fate in both embryos and adults.
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Gan to kagaku ryoho. Cancer & chemotherapy, 1997
The APC gene is mutated in the majority of colorectal tumors. The product of this gene is a 300 kDa protein associated with beta-catenin and the human homolog of the Drosophila tumor suppressor DLG. The study of the function of APC provides important insights into the mechanisms of the development of colorectal tumor.
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The APC gene is mutated in the majority of colorectal tumors. The product of this gene is a 300 kDa protein associated with beta-catenin and the human homolog of the Drosophila tumor suppressor DLG. The study of the function of APC provides important insights into the mechanisms of the development of colorectal tumor.
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Cancer research, 2001
Beta-catenin undergoes both serine and tyrosine phosphorylation. Serine phosphorylation in the amino terminus targets beta-catenin for proteasome degradation, whereas tyrosine phosphorylation in the COOH terminus influences interaction with E-cadherin.
BONVINI P. +7 more
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Beta-catenin undergoes both serine and tyrosine phosphorylation. Serine phosphorylation in the amino terminus targets beta-catenin for proteasome degradation, whereas tyrosine phosphorylation in the COOH terminus influences interaction with E-cadherin.
BONVINI P. +7 more
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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Signal Transduction and Targeted Therapy, 2022Jiaqi Liu, Yuanyuan Li, Xiaojun Zhang
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