Results 61 to 70 of about 45,886 (260)

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

The association between plasma betaine level and brain structural changes in schizophrenia

Schizophrenia
Previous studies on metabolic profiling have shown decreased plasma levels of betaine in schizophrenia. Betaine serves as a substrate of betaine-homocysteine methyltransferase, which converts homocysteine to methionine.
Favour Omileke, Tempei Ikegame, Shimon Tonsho, Shunsuke Mori, Eimu Shoji, Masahiro Kiyota, Takuto Minami, Eureka Kumagai, Tatsuro Asai, Kenji Kirihara, Shinsuke Koike, Seiichiro Jinde, Kouhei Kamiya, Osamu Abe, Kiyoto Kasai, Naohiro Okada   +15 more
doaj   +1 more source

Hypertensive rats show increased renal excretion and decreased tissue concentrations of glycine betaine, a protective osmolyte with diuretic properties.

PLoS ONE
Hypertension leads to water-electrolyte disturbances and end-organ damage. Betaine is an osmolyte protecting cells against electrolyte imbalance and osmotic stress, particularly in the kidneys.
Izabella Mogilnicka, Kinga Jaworska, Mateusz Koper, Klaudia Maksymiuk, Mateusz Szudzik, Mariusz Radkiewicz, Dawid Chabowski, Marcin Ufnal   +7 more
doaj   +1 more source

Glycine Betaine Recognition through Cation−π Interactions in Crystal Structures of Glycine Betaine Complexes with C-Ethyl-pyrogallol[4]arene and C-Ethyl-resorcin[4]arene as Receptors

Crystals, 2013
The glycine betaine (betaine), interacts with several types of proteins with diverse structures in vivo, and in the contact regions, the aromatic rings of protein residues are frequently found beside the trimethylammonium group of betaine, implying the ...
Ikuhide Fujisawa, Katsuyuki Aoki
doaj   +1 more source

Isotellurourea‐Catalyzed Enantioselective (4+2)‐Heterocycloadditions of But‐2‐ynoates and Michael Acceptors

European Journal of Organic Chemistry, EarlyView.
Isotelluroureas allow for the use of alkynoates for asymmetric (4+2)‐heterocycloadditions with different Michael acceptors. Alk‐2‐ynoates are readily available starting materials which, in principle, can be utilized for cycloadditions in analogy to structurally similar allenoates.
Anna Scheucher, Mario Waser
wiley   +1 more source

Cyclodextrins as Chiral Selectors in Capillary Electrophoresis—Recent Developments in Understanding Analyte Complexation and Applications in Pharmaceutical Analysis

ELECTROPHORESIS, EarlyView.
Cyclodextrins are the most often applied chiral selectors in CE enantioseparations. In combination with NMR spectroscopy and molecular modeling, studies for an understanding of chiral recognition underlying enantioseparations have been performed.
Gerhard K. E. Scriba
wiley   +1 more source

Enabling Ultrastable Microbubbles With Graphene Aerogel Enrichment and Machine Learning for Highly Efficient Carbon Storage

Electron, EarlyView.
This study aims to introduce a novel‐designed structure of the colloidal aphron microbubbles reinforced by incorporating hydrophobic aerographene microparticles onto the hydrophobic outer shell. This results in the formation of a robust composite film and armored microbubble that offers exceptional ultrastability under elevated pressures of up to 400 ...
Mohammad Hossein Akhlaghi, Malek Naderi, Ali Pilehvar Meibody, Shurui Yang, Mojtaba Abdi‐Jalebi   +4 more
wiley   +1 more source

Association between dietary betaine intake and overweight or obesity

Scientific Reports
Betaine exhibits significant physiological functions in organisms and has positive impacts on obesity, alcohol-induced and metabolic-associated liver disease, diabetes, cardiovascular diseases, and certain cancers.
Maierheba Kuerbanjiang, Wenzhuo Yu, Ting Shang, Yuchen Liu, Dina Muheyati, Mei-Xia Lv, Muhairemu Jielili, Jia Han   +7 more
doaj   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Daidzein-betaine cocrystal alleviates high-energy and low-protein diet induced fatty liver hemorrhagic syndrome in laying hens through gut-liver axis

Poultry Science
Fatty liver hemorrhagic syndrome (FLHS) severely endangers the health and productivity of laying hens, marked by hepatic steatosis and impaired lipid metabolism. Daidzein-betaine cocrystal improves lipid metabolism in the diet-induced obesity mice.
Yanling Sun, Tiantian Wang, Yu Zhang, Ning Ma, Xinghua Zhao, Xin He   +5 more
doaj   +1 more source