Results 51 to 60 of about 72,341 (282)

Transcription factor TCF4: structure, function, and associated diseases

Вавиловский журнал генетики и селекции
Our understanding of human genes - particularly their structure, functions, and regulatory mechanisms - is still limited. The biological role of approximately 20 % of human proteins has not been established yet, and the molecular functions of the known ...
R. R. Savchenko, N. A. Skryabin
doaj   +1 more source

Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10 [PDF]

, 2013
The plant hormone jasmonate (JA) activates gene expression by promoting ubiquitin-dependent degradation of JAZ transcriptional repressor proteins. A key feature of all JAZ proteins is the highly conserved Jas motif, which mediates both JAZ degradation ...
Campos, Marcelo L., Chung, Hoo Sun, He, Sheng Hang, Howe, Gregg A., Moreno, Javier Edgardo, Patel, Lalita C., Shyu, Christine, Yao, Jian   +7 more
core   +1 more source

Early evolution of bHLH proteins in plants [PDF]

Plant Signaling & Behavior, 2010
Basic-helix-loop-helix (bHLH) proteins are a large family of eukaryotic transcription factors. In plants, they have been shown to be key regulators of a diverse array of developmental and metabolic pathways. We have recently shown that the diversity of bHLH proteins in angiosperms is ancient.
Pires, N, Dolan, L
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Genome-wide identification and expression analysis of the bHLH transcription factor family and its response to abiotic stress in sorghum [Sorghum bicolor (L.) Moench]

BMC Genomics, 2021
Background Basic helix-loop-helix (bHLH) is a superfamily of transcription factors that is widely found in plants and animals, and is the second largest transcription factor family in eukaryotes after MYB.
Yu Fan, Hao Yang, Dili Lai, Ailing He, Guoxing Xue, Liang Feng, Long Chen, Xiao-bin Cheng, Jingjun Ruan, Jun Yan, Jianping Cheng   +10 more
doaj   +1 more source

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Investigations of the CLOCK and BMAL1 Proteins Binding to DNA: A Molecular Dynamics Simulation Study. [PDF]

PLoS ONE, 2016
The circadian locomotor output cycles kaput (CLOCK), and brain and muscle ARNT-like 1 (BMAL1) proteins are important transcriptional factors of the endogenous circadian clock.
Tuo Xue, Chunnian Song, Qing Wang, Yan Wang, Guangju Chen   +4 more
doaj   +1 more source

Functional Profiling of Transcription Factor Genes in Neurospora crassa. [PDF]

, 2017
Regulation of gene expression by DNA-binding transcription factors is essential for proper control of growth and development in all organisms. In this study, we annotate and characterize growth and developmental phenotypes for transcription factor genes ...
Bekman, Thomas, Blahut, Johnathon, Borkovich, Katherine A, Cabrera, Ilva E, Carrera, Cristian, Carrillo, Alexander J, Chen, Vivian, Clark, Isaiah, Dietrich, Sarah, Fierro, Gerardo, Ganzen, Logan, Mei, Jennifer, Orellana, Jose, Prudhomme, Loren, Schacht, Patrick, Wise, Shelby, Yang, Kevin, Zhong, Hui   +17 more
core   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source