Results 11 to 20 of about 38,093 (162)

Mechanisms of Binding Specificity among bHLH Transcription Factors [PDF]

International Journal of Molecular Sciences, 2021
The transcriptome of every cell is orchestrated by the complex network of interaction between transcription factors (TFs) and their binding sites on DNA. Disruption of this network can result in many forms of organism malfunction but also can be the substrate of positive natural selection.
Xabier de Martin, Reza Sodaei, Gabriel Santpere   +2 more
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A bHLH transcription factor, SlbHLH96, promotes drought tolerance in tomato. [PDF]

Hortic Res, 2022
Abstract Drought stress caused by water deficit reduces plant productivity in many regions of the world. In plants, basic helix–loop–helix (bHLH) transcription factors regulate a wide range of cellular activities related to growth, development and stress response; however, the role of tomato SlbHLHs in drought stress responses remains ...
Liang Y, Ma F, Li B, Guo C, Hu T, Zhang M, Liang Y, Zhu J, Zhan X.   +8 more
europepmc   +3 more sources

Structural characterization of mammalian bHLH-PAS transcription factors [PDF]

Current Opinion in Structural Biology, 2017
The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1.
Dalei, Wu, Fraydoon, Rastinejad
openaire   +3 more sources

The bHLH Transcription Factor OsbHLH057 Regulates Iron Homeostasis in Rice. [PDF]

Int J Mol Sci, 2022
Many basic Helix-Loop-Helix (bHLH) transcription factors precisely regulate the expression of Fe uptake and translocation genes to control iron (Fe) homeostasis, as both Fe deficiency and toxicity impair plant growth and development. In rice, three clade IVc bHLH transcription factors have been characterised as positively regulating Fe-deficiency ...
Wang W, Shinwari KI, Zhang H, Zhang H, Dong L, He F, Zheng L.   +6 more
europepmc   +3 more sources

RFP represses transcriptional activation by bHLH transcription factors [PDF]

Oncogene, 2005
Basic helix-loop-helix (bHLH) transcription factors play a pivotal role in the regulation of tumorigenesis, and also in a wide range of other developmental processes in diverse species from yeast to humans. Here we demonstrate for the first time that Ret finger protein (RFP), a member of the TRIM family of proteins initially identified as a recombined ...
Adrian J C, Bloor, Ekaterina, Kotsopoulou, Penny, Hayward, Brian R, Champion, Anthony R, Green   +4 more
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bHLH-Orange Transcription Factors in Development and Cancer [PDF]

Translational Oncogenomics, 2007
Basic helix-loop-helix (bHLH) proteins are a large superfamily of transcription factors that play critical roles in many physiological processes including cellular differentiation, cell cycle arrest and apoptosis. Based on structural and phylogenetic analysis, mammalian bHLH-Orange (bHLH-O) proteins, which constitute the repressor family of bHLH ...
Hong, Sun, Saghi, Ghaffari, Reshma, Taneja   +2 more
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Cooperation between bHLH transcription factors and histones for DNA access [PDF]

Nature, 2023
AbstractThe basic helix–loop–helix (bHLH) family of transcription factors recognizes DNA motifs known as E-boxes (CANNTG) and includes 108 members1. Here we investigate how chromatinized E-boxes are engaged by two structurally diverse bHLH proteins: the proto-oncogene MYC-MAX and the circadian transcription factor CLOCK-BMAL1 (refs. 2,3).
Alicia K. Michael, Lisa Stoos, Priya Crosby, Nikolas Eggers, Xinyu Y. Nie, Kristina Makasheva, Martina Minnich, Kelly L. Healy, Joscha Weiss, Georg Kempf, Simone Cavadini, Lukas Kater, Jan Seebacher, Luca Vecchia, Deyasini Chakraborty, Luke Isbel, Ralph S. Grand, Florian Andersch, Jennifer L. Fribourgh, Dirk Schübeler, Johannes Zuber, Andrew C. Liu, Peter B. Becker, Beat Fierz, Carrie L. Partch, Jerome S. Menet, Nicolas H. Thomä   +26 more
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Genome-Wide Characterization and Analysis of bHLH Transcription Factors Related to Anthocyanin Biosynthesis in Fig (Ficus carica L.)

Frontiers in Plant Science, 2021
The basic helix–loop–helix (bHLH) transcription factor family is the second largest transcription factor family in plants, and participates in various plant growth and development processes.
Miaoyu Song, Haomiao Wang, Zhe Wang, Hantang Huang, Shangwu Chen, Huiqin Ma, Huiqin Ma   +6 more
doaj   +1 more source

Regulatory Potential of bHLH-Type Transcription Factors on the Road to Rubber Biosynthesis in Hevea brasiliensis

Plants, 2020
Natural rubber is the main component of latex obtained from laticifer cells of Hevea brasiliensis. For improving rubber yield, it is essential to understand the genetic molecular mechanisms responsible for laticifer differentiation and rubber ...
Tomoko Yamaguchi, Yukio Kurihara, Yuko Makita, Emiko Okubo-Kurihara, Ami Kageyama, Emi Osada, Setsuko Shimada, Hiroko Tsuchida, Hiroaki Shimada, Minami Matsui   +9 more
doaj   +1 more source

TWIST2 (twist family BHLH transcription factor 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2015
Review on TWIST2 (twist family BHLH transcription factor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Gasparotto, D, Lorenzetto, E
openaire   +2 more sources