Results 251 to 260 of about 63,274 (284)

Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist

Science, 1996
The myogenic basic helix-loop-helix (bHLH) and MEF2 transcription factors are expressed in the myotome of developing somites and cooperatively activate skeletal muscle gene expression. The bHLH protein Twist is expressed throughout the epithelial somite and is subsequently excluded from the myotome.
D B, Spicer, J, Rhee, W L, Cheung, A B, Lassar   +3 more
openaire   +2 more sources

bHLH Transcription factors and mammalian neuronal differentiation

The International Journal of Biochemistry & Cell Biology, 1997
The basic helix-loop-helix (bHLH) factor Mash1 is expressed in the developing nervous system. Null mutation of Mash1 results in loss of olfactory and autonomic neurons and delays differentiation of retinal neurons, indicating that Mash1 promotes neuronal differentiation.
R, Kageyama, M, Ishibashi, K, Takebayashi, K, Tomita   +3 more
openaire   +2 more sources

Hey bHLH Transcription Factors

2014
Hey bHLH transcription factors are direct targets of canonical Notch signaling. The three mammalian Hey proteins are closely related to Hes proteins and they primarily repress target genes by either directly binding to core promoters or by inhibiting other transcriptional activators.
David, Weber, Cornelia, Wiese, Manfred, Gessler   +2 more
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Sohlh2 is a germ cell-specific bHLH transcription factor

Gene Expression Patterns, 2006
Germ cell-specific transcriptional regulation is essential to understand pathways that confer germ cells their unique biology. Germ cell-specific transcription factors such as Figla and Nobox are critical in oogenesis, while Zfp148 and Taf4b are also critical in spermatogenesis.
Daniel J, Ballow, Yun, Xin, Youngsok, Choi, Stephanie A, Pangas, Aleksandar, Rajkovic   +4 more
openaire   +2 more sources

A Role for Hath1, a bHLH Transcription Factor, in Colon Adenocarcinoma

Annals of the New York Academy of Sciences, 2005
Abstract: A significant reduction or loss of goblet cells is often observed in clinical samples of colon adenocarcinomas, which is the predominant form of colon carcinoma. Mice lacking Math1, a bHLH transcription factor downstream of the Notch signaling pathway, demonstrates that Math1 is necessary for cell fate determination of the intestinal ...
Ching Ching, Leow, Paul, Polakis, Wei-Qiang, Gao   +2 more
openaire   +2 more sources

The evolution and structure/function of bHLH–PAS transcription factor family

Biochemical Society Transactions, 2022
Proteins that contain basic helix-loop-helix (bHLH) and Per-Arnt-Sim motifs (PAS) function as transcription factors. bHLH–PAS proteins exhibit essential and diverse functions throughout the body, from cell specification and differentiation in embryonic development to the proper function of organs like the brain and liver in adulthood. bHLH–PAS proteins
Hailey E. Edwards, Daniel A. Gorelick
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A Role for bHLH Transcription Factors in Retinal Degeneration and Dysfunction

2007
The basic helix loop helix (bHLH) transcription factors collectively mediate cellular differentiation in almost every type of tissue including the retina (Murre et al. 1989; Jan and Jan 1993; Cepko 1999). Class A factors are ubiquitously expressed throughout mammalian tissue, while the expression of class B factors are cell type specific. These factors
Mark E, Pennesi, Debra E, Bramblett, Jang-Hyeon, Cho, Ming-Jer, Tsai, Samuel M, Wu   +4 more
openaire   +2 more sources

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

Nature Genetics, 1998
The placenta and cardiovascular system are the first organ systems to form during mammalian embryogenesis. We show here that a single gene is critical for development of both. The Hand1 gene, previously called Hxt, eHAND and Thing1, encodes a basic helix-loop-helix (bHLH) transcription factor that starts to be expressed during pre-implantation ...
P, Riley, L, Anson-Cartwright, J C, Cross   +2 more
openaire   +2 more sources

Analysis of the bHLH Transcription Factors Olig1 and Olig2 in Brain Tumors

Journal of Neuro-Oncology, 2004
In the absence of specific markers, the histological diagnosis of oligodendroglial tumors is based on subjective qualitative criteria and remains controversial. Recently, two bHLH transcription factors involved in oligodendroglial specification, Olig1 and Olig2 have been proposed as potential markers of oligodendrogliomas.
Lucinda, Aguirre-Cruz, Karima, Mokhtari, Khê, Hoang-Xuan, Yannick, Marie, Emmanuelle, Criniere, Sophie, Taillibert, Manuel, Lopes, Jean-Yves, Delattre, Marc, Sanson   +8 more
openaire   +2 more sources

Remodeling of the hypertrophied human myocardium by cardiac bHLH transcription factors

Journal of Cellular Biochemistry, 1999
The basic helix-loop-helix transcription factors eHAND and dHAND are involved in developmental cardiac growth and differentiation. We investigated HAND gene expression in the normal and in the hypertrophied right and left ventricle of patients with tetralogy of Fallot (ToF) and hypertrophic obstructive cardiomyopathy (HOCM).
O, Ritter, H, Haase, H D, Schulte, P E, Lange, I, Morano   +4 more
openaire   +2 more sources