Results 1 to 10 of about 36,123 (95)
Mechanisms of Binding Specificity among bHLH Transcription Factors. [PDF]
Int J Mol Sci, 2021 The transcriptome of every cell is orchestrated by the complex network of interaction between transcription factors (TFs) and their binding sites on DNA. Disruption of this network can result in many forms of organism malfunction but also can be the substrate of positive natural selection.
de Martin X, Sodaei R, Santpere G.
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Cooperation between bHLH transcription factors and histones for DNA access. [PDF]
Nature, 2023 AbstractThe basic helix–loop–helix (bHLH) family of transcription factors recognizes DNA motifs known as E-boxes (CANNTG) and includes 108 members1. Here we investigate how chromatinized E-boxes are engaged by two structurally diverse bHLH proteins: the proto-oncogene MYC-MAX and the circadian transcription factor CLOCK-BMAL1 (refs. 2,3).
Michael AK +26 more
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Current Understanding of bHLH Transcription Factors in Plant Abiotic Stress Tolerance. [PDF]
Int J Mol Sci, 2021 Named for the characteristic basic helix-loop-helix (bHLH) region in their protein structure, bHLH proteins are a widespread transcription factor class in eukaryotes. bHLHs transcriptionally regulate their target genes by binding to specific positions on their promoters and thereby direct a variety of plant developmental and metabolic processes, such ...
Guo J +5 more
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Structural characterization of mammalian bHLH-PAS transcription factors [PDF]
Current Opinion in Structural Biology, 2017 The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1.
Dalei, Wu, Fraydoon, Rastinejad
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RFP represses transcriptional activation by bHLH transcription factors [PDF]
Oncogene, 2005 Basic helix-loop-helix (bHLH) transcription factors play a pivotal role in the regulation of tumorigenesis, and also in a wide range of other developmental processes in diverse species from yeast to humans. Here we demonstrate for the first time that Ret finger protein (RFP), a member of the TRIM family of proteins initially identified as a recombined ...
Adrian J C, Bloor +4 more
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bHLH-Orange Transcription Factors in Development and Cancer [PDF]
Translational Oncogenomics, 2007 Basic helix-loop-helix (bHLH) proteins are a large superfamily of transcription factors that play critical roles in many physiological processes including cellular differentiation, cell cycle arrest and apoptosis. Based on structural and phylogenetic analysis, mammalian bHLH-Orange (bHLH-O) proteins, which constitute the repressor family of bHLH ...
Hong, Sun +2 more
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TWIST2 (twist family BHLH transcription factor 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2015 Review on TWIST2 (twist family BHLH transcription factor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Gasparotto, D, Lorenzetto, E
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Mutation of a bHLH transcription factor allowed almond domestication [PDF]
Science, 2019 How to make almonds palatable The domesticated almond tree has been feeding humans for millennia. Derivation from the wild, bitter, and toxic almond required loss of the cyanogenic diglucoside amygdalin. Sánchez-Pérez et al.
R. Sánchez-Pérez1 +23 more
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A bHLH transcription factor, SlbHLH96, promotes drought tolerance in tomato
Horticulture Research, 2022 Abstract Drought stress caused by water deficit reduces plant productivity in many regions of the world. In plants, basic helix–loop–helix (bHLH) transcription factors regulate a wide range of cellular activities related to growth, development and stress response; however, the role of tomato SlbHLHs in drought stress responses remains ...
Liang, Yunfei +8 more
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MYC (MYC proto-oncogene, bHLH transcription factor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Review the structure, function, and role of CMYC gene in ...
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