Results 41 to 50 of about 2,675 (155)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma

Molecular Therapy: Oncolytics, 2015
Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the replication and ...
Breanne P Cuddington, Meghan Verschoor, Ali Ashkar, Karen L Mossman   +3 more
doaj   +1 more source

Knee‐ABC 2 reduces acute, severe and overuse knee injuries

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Handball is associated with a high risk of knee injury. This study investigated whether an injury prevention program is effective in reducing acute, severe and overuse knee injuries in handball athletes. Methods Sixty‐nine men's and women's handball teams (U‐15, U‐17, U‐19 and senior athletes) were cluster‐randomised into an ...
Leonard Achenbach, Gunnar Huppertz, Karolina Müller, Florian Zeman, Maximilian Rudert, Kai Fehske   +5 more
wiley   +1 more source

BVDV and BHV-1 Infections in Dairy Herds in Northern and Northeastern Thailand

Acta Veterinaria Scandinavica, 2004
Bulk milk samples from 220 dairy herds were collected at 9 public milk collection centres in the northeastern and northern Thailand, and a subset of 11 herds was selected for individual testing. The samples were tested for presence of antibodies to BVDV
Chanlun A, Moreno-López J, Ståhl K, Kampa J, Aiumlamai S, Alenius S   +5 more
doaj   +1 more source

Proteção contra infecções pelo BHV-5 induzida por uma vacina para BHV-1 e por uma amostra recombinante de BHV-5

Acta Scientiae Veterinariae, 2018
O herpesvirus bovino tipo 5 (BHV-5) e responsavel por meningoencefalites necrosantes em bovinos, com prevalencia aparentemente mais significativa nos paises do hemisferio sul, principalmente Brasil e Argentina. Objetivando um melhor entendimento sobre aspectos de protecao cruzada induzida atraves da utilizacao de vacinas contra BHV-1 frente a infeccoes
openaire   +3 more sources

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley   +1 more source

Proteolytic Degradation Is a Major Contributor to Bioprosthetic Heart Valve Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Whereas the risk factors for structural valve degeneration (SVD) of glutaraldehyde‐treated bioprosthetic heart valves (BHVs) are well studied, those responsible for the failure of BHVs fixed with alternative next‐generation chemicals remain ...
Alexander E. Kostyunin, Tatiana V. Glushkova, Arseniy A. Lobov, Evgeny A. Ovcharenko, Bozhana R. Zainullina, Leo A. Bogdanov, Daria K. Shishkova, Victoria E. Markova, Maksim A. Asanov, Rinat A. Mukhamadiyarov, Elena A. Velikanova, Tatiana N. Akentyeva, Maria A. Rezvova, Alexander N. Stasev, Alexey V. Evtushenko, Leonid S. Barbarash, Anton G. Kutikhin   +16 more
doaj   +1 more source

Reducing Trade‐Offs of Net Zero Carbon Transitions Through Entrepreneurship and Coordinated Innovation: A Spatially Disaggregated Analysis Across Countries and World Regions

Sustainable Development, Volume 34, Issue 4, Page 4787-4805, August 2026.
ABSTRACT Transition processes towards a sustainable future benefit from historic perspectives, since feasible changes of socio‐technological conditions and processes depend on a holistic assessment of how actors are embedded in existing institutions, routines, and structures. Building on the Income–Population–Affluence–Technology equation and utilizing
Jessica Kluge, Marcus Wagner
wiley   +1 more source

CD335 (NKp46)+ T-Cell Recruitment to the Bovine Upper Respiratory Tract during a Primary Bovine Herpesvirus-1 Infection

Frontiers in Immunology, 2017
Bovine natural killer (NK) cells were originally defined by the NK activation receptor CD335 [natural killer cell p46-related protein (NKp46)], but following the discovery of NKp46 expression on human T-cells, the definition of conventional bovine NK ...
Rahwa A. Osman, Rahwa A. Osman, Philip John Griebel, Philip John Griebel   +3 more
doaj   +1 more source