Results 231 to 240 of about 20,682 (267)

A Sequential Probability Ratio Test Using a Biased Coin Design

Annals of Statistics, 1985
Consider a sequential probability ratio test comparing two treatments, where each subject receives only one of the treatments. Each subject's treatment assignment is determined by the flip of a biased coin, where the bias serves to balance the number of patients assigned to each treatment.
Nancy E Heckman
exaly   +3 more sources

A Local Limit Theorem for a Biased Coin Design for Sequential Tests

Annals of Statistics, 1985
In a clinical comparison of responses to two treatments, patients are admitted sequentially and given one of the two treatments. The allocation is determined randomly, to decrease the possibility of personal bias in the selection of subjects for the test.
Nancy E Heckman
exaly   +3 more sources

Sequential Treatment Allocation Using Biased Coin Designs

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1984
SUMMARY Biased coin designs are used in clinical trials as a means of achieving approximate balance within a randomized design. In this paper, detailed results are obtained for a class of biased coin designs from the point of view of the degree of balance achieved, selection bias, accidental bias and inference following the randomized ...
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Biased coin design with imbalance tolerance

Stochastic Models, 1999
Summary: One of the main aspects of a sampling procedure is to determine how to collect samples. A completely random sampling scheme is free of any bias and provides a basis for valid statistical inferences. A balanced sampling scheme strengthens efficiency in statistical inference procedures.
exaly   +2 more sources

Biased coin designs with a Bayesian bias

Journal of Statistical Planning and Inference, 1993
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
F. BALL, A. F. M. SMITH, VERDINELLI, Isabella   +2 more
openaire   +2 more sources

Properties of Biased Coin Designs in Sequential Clinical Trials

Annals of Statistics, 1984
Several authors have proposed and studied designs in a clinical trial experiment of testing treatments. For example \textit{B. Efron} [cf. Biometrika 58, 403-417 (1971; Zbl 0226.62086)] proposed and studied a sequential biased design for two treatments \(R=2\).
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The Accelerated Biased Coin Up-and-Down Design in Phase I Trials

Journal of Biopharmaceutical Statistics, 2004
The biased coin up-and-down design (BCD) is used to allocate doses in phase I clinical trials. The BCD requires that the treatment response or the toxicity evaluation is observed quickly. In trials with a long treatment evaluation, the BCD will lead to long trial duration because a new patient cannot be enrolled until the preceding patient has ...
Dean Follmann
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Bayesian Adaptive Biased-Coin Designs for Clinical Trials with Normal Responses

Biometrics, 2005
Summary Adaptive designs are used in phase III clinical trials for skewing the allocation pattern toward the better treatments. We use optimum design theory to derive a skewed Bayesian biased‐coin procedure for sequential designs with continuous responses.
Anthony C Atkinson, Atanu Biswas
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Doubly adaptive biased coin designs with delayed responses

Canadian Journal of Statistics, 2008
AbstractIn clinical studies, patients are usually accrued sequentially. Response‐adaptive designs are then useful tools for assigning treatments to incoming patients as a function of the treatment responses observed thus far. In this regard, doubly adaptive biased coin designs have advantageous properties under the assumption that their responses can ...
Feifang Hu, Li-Xin Zhang, Siu Hung Cheung   +2 more
exaly   +3 more sources

Doubly adaptive biased coin designs with heterogeneous responses

Journal of Statistical Planning and Inference, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Feifang Hu
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