Results 181 to 190 of about 11,641 (225)

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

, 2023
Yadav MK, Sarma P, Ganguly M, Mishra S, Maharana J, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK.   +13 more
europepmc   +1 more source

TAS2R5 screening reveals biased agonism that fails to evoke internalization and downregulation resulting in attenuated desensitization. [PDF]

PLoS One
Kim D, Strzelinski HR, Liggett SB.
europepmc   +1 more source

Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH₂. [PDF]

J Med Chem, 2020
Pacifico S, Ferrari F, Albanese V, Marzola E, Neto JA, Ruzza C, Calò G, Preti D, Guerrini R.   +8 more
europepmc   +1 more source

GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. [PDF]

Commun Biol
Matthees ESF, Filor JC, Jaiswal N, Reichel M, Youssef N, D'Uonnolo G, Szpakowska M, Drube J, König GM, Kostenis E, Chevigné A, Godbole A, Hoffmann C.   +12 more
europepmc   +1 more source

Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases. [PDF]

Am J Respir Cell Mol Biol
Shah SD, Deshpande DA.
europepmc   +1 more source

Biased agonism of protease-activated receptor-1 regulates thromboinflammation in murine sickle cell disease. [PDF]

Blood Adv
Ramadas N, Lowder K, Dutton J, Trebak F, Faes C, Griffin JH, Pawlinski R, Mosnier LO, Sparkenbaugh E.   +8 more
europepmc   +1 more source

Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds. [PDF]

ACS Pharmacol Transl Sci, 2020
Wouters E, Walraed J, Robertson MJ, Meyrath M, Szpakowska M, Chevigné A, Skiniotis G, Stove C.   +7 more
europepmc   +1 more source

Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism. [PDF]

J Biol Chem
Rodriguez P, Laskowski LJ, Pallais JP, Bock HA, Cavalco NG, Anderson EI, Calkins MM, Razzoli M, Sham YY, McCorvy JD, Bartolomucci A.   +10 more
europepmc   +1 more source

Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A_2A receptor. [PDF]

Comput Struct Biotechnol J, 2020
Navarro G, Gonzalez A, Campanacci S, Rivas-Santisteban R, Reyes-Resina I, Casajuana-Martin N, Cordomí A, Pardo L, Franco R.   +8 more
europepmc   +1 more source

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. [PDF]

Nat Commun
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK.   +13 more
europepmc   +1 more source