Results 211 to 220 of about 11,641 (225)
Some of the next articles are maybe not open access.

Understanding biased agonism at the dopamine D₂ receptor

2017
The phenomenon of “biased agonism” presents an attractive avenue for drug development as it allows the separation of therapeutic effects from side effects mediated by the same target. A prototypical G protein-coupled receptor at which biased agonism has been extensively studied is the dopamine D₂ receptor, an important therapeutic target for current ...
openaire   +1 more source

Biased Agonism

2010
Peter J. Tyrer   +81 more
openaire   +1 more source

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

Neuropharmacology, 2020
Emil Marcher-Rørsted   +2 more
exaly  

Biased Agonism at G Protein‐Coupled Receptors: The Promise and the Challenges—A Medicinal Chemistry Perspective

Medicinal Research Reviews, 2014
Jeremy Shonberg   +2 more
exaly  

Quantifying biased agonism: understanding the links between affinity and efficacy

Nature Reviews Drug Discovery, 2013
Sudarshan Rajagopal
exaly  

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

Journal of Biological Chemistry, 2015
Gyslaine Bertrand   +2 more
exaly  

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Nature Reviews Molecular Cell Biology, 2018
Denise Wootten   +2 more
exaly  

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