Results 91 to 100 of about 185,950 (192)

Strong gender differences in reproductive success variance, and the times to the most recent common ancestors

, 2012
The Time To the Most Recent Common Ancestor (TMRCA) based on human mitochondrial DNA (mtDNA) is estimated to be twice that based on the non-recombining part of the Y chromosome (NRY).
Barber, Bateman, Baumeister, Bowles, Burkart, Campbell, Cann, Coates, Cox, Darcet, Didier Sornette, Dunbar, Eriksson, Fisher, Geary, Gurven, Hammer, Hammer, Hedrick, Helgason, Hill, Hill, Hon, Ingman, Jasienska, Konner, Kuo, Langergraber, Marlowe, Marlowe, Maroussia Favre, Moran, Moran, Niederle, Ogas, Orians, Pritchard, Seielstad, Sutherland, Tang, Thomson, Tremblay, Verner, Wakeley, Wilder, Wilder, Wilkins, Wright, Zahavi   +48 more
core   +1 more source

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling [PDF]

, 2018
Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro ...
Benovic, Jeffrey L., Carter, Rhonda L., de Lucia, Claudio, Gao, Erhe, Grisanti, Laurel A., Koch, Walter J., Thomas, Toby P., Tilley, Douglas G.   +7 more
core   +1 more source

Biased signalling in analgesic research and development

Current Opinion in Pharmacology
Ligand bias offers a novel means to improve the therapeutic profile of drugs. With regard to G protein-coupled receptors involved in analgesia, it could be advantageous to develop such drugs if the analgesic effect is mediated by a different cellular signalling pathway than the adverse effects associated with the drug.
Alexandra, Conibear, Chris P, Bailey, Eamonn, Kelly   +2 more
openaire   +2 more sources

Simulating quantum correlations as a distributed sampling problem

, 2005
It is known that quantum correlations exhibited by a maximally entangled qubit pair can be simulated with the help of shared randomness, supplemented with additional resources, such as communication, post-selection or non-local boxes.
J. S. Bell, Julien Degorre, Jérémie Roland, L. Devroye, S. Popescu, Sophie Laplante   +5 more
core   +1 more source

Environmental control of microtubule-based bidirectional cargo-transport

, 2014
Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion.
Appert-Rolland, Cécile, Klein, Sarah, Santen, Ludger   +2 more
core   +3 more sources

Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human μ‐opiate receptor 1 (OPRM1) expressing cells

Pharmacology Research & Perspectives, 2019
Opioids are powerful analgesics acting via the human μ‐opiate receptor (hMOR). Opioid use is associated with adverse effects such as tolerance, addiction, respiratory depression, and constipation.
Tom Hsu, Jayapal R. Mallareddy, Kayla Yoshida, Vincent Bustamante, Tim Lee, John L. Krstenansky, Alexander C. Zambon   +6 more
doaj   +1 more source

Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

eLife
New psychoactive substances (NPS) targeting human cannabinoid receptor 1 pose a significant threat to society as recreational abusive drugs that have pronounced physiological side effects.
Soumajit Dutta, Diwakar Shukla
doaj   +1 more source

Local synaptic signaling enhances the stochastic transport of\ud motor-driven cargo in neurons [PDF]

, 2010
The tug-of-war model of motor-driven cargo transport is formulated as an intermittent trapping process. An immobile trap, representing the cellular machinery that sequesters a motor-driven cargo for eventual use, is located somewhere within a microtubule
Bressloff, P. C., Newby, J. M.
core  

Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery

Pharmacological Research
G protein-coupled receptors (GPCRs) represent the largest family of membrane receptors and are highly effective targets for therapeutic drugs. GPCRs couple different downstream effectors, including G proteins (such as Gi/o, Gs, G12, and Gq) and β ...
Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen   +6 more
doaj   +1 more source

The role of kinetic context in apparent biased agonism at GPCRs

Nature Communications, 2016
Biased agonists act at a receptor to preferentially induce distinct intracellular signalling responses over others. Here the authors show how kinetics of ligand binding and signaling responses greatly influence observed bias profiles, and hence must be ...
Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos, J. Robert Lane   +12 more
doaj   +1 more source