Results 11 to 20 of about 187,893 (285)
Biased Signaling of Protease-activated Receptors [PDF]
Frontiers in Endocrinology, 2014 In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain and repair mechanisms.
Peishen eZhao +3 more
doaj +4 more sources
Biased Signaling in Psychedelic Action. [PDF]
Annu Rev Pharmacol ToxicolPsychedelics show tremendous promise for treating psychiatric disorders and other illnesses, including pain and migraine. Despite decades of research, there is uncertainty which signaling mechanisms are necessary for rapid-acting and durable therapeutic effects of psychedelics. Although activation of the serotonin 5-HT
Wacker D, McCorvy JD.
europepmc +4 more sources
Corrigendum: Biased signaling of protease-activated receptors [PDF]
Frontiers in Endocrinology, 2015 Figure Figure33 shows a snake diagram of the N-terminal amino acid sequence of human protease-activated receptor (PAR2). It indicates the sites at which different proteases cleave PAR2. These sites are correct. The error is that we accidentally repeated a sequence of amino acid residues (11–16, GAAILL) in positions 17–22 of the snake diagram.
Peishen eZhao +3 more
doaj +3 more sources
Agonist concentration–dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Junlin Wang, Richard D Ye
exaly +2 more sources
Biased Signaling at Chemokine Receptors [PDF]
Journal of Biological Chemistry, 2015 The ability of G protein-coupled receptors (GPCRs) to activate selective signaling pathways according to the conformation stabilized by bound ligands (signaling bias) is a challenging concept in the GPCR field. Signaling bias has been documented for several GPCRs, including chemokine receptors.
Corbisier, Jenny +4 more
openaire +3 more sources
Frontiers in Chemistry, 2021 Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug targets because they can produce fewer on-target side effects, improved selectivity, and better biological specificity (e.g., biased signaling or probe dependence) than
Keith M. Olson +4 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Seven transmembrane receptors (7TMRs), often termed G protein-coupled receptors (GPCRs), are the most common target of therapeutic drugs used today. Many studies suggest that distinct members of the GPCR superfamily represent potential targets for the ...
Camila Oliveira de Souza +2 more
doaj +1 more source
Structure, Function, and Pharmaceutical Ligands of 5-Hydroxytryptamine 2B Receptor
Pharmaceuticals, 2021 Since the first characterization of the 5-hydroxytryptamine 2B receptor (5-HT2BR) in 1992, significant progress has been made in 5-HT2BR research. Herein, we summarize the biological function, structure, and small-molecule pharmaceutical ligands of the 5-
Qing Wang +3 more
doaj +1 more source
Was that a threat? Attentional biases by signals of threat. [PDF]
Emotion, 2017 The present study rigorously tests whether an arbitrary stimulus that signals threat affects attentional selection and perception. Thirty-four volunteers completed a spatial-emotional cueing paradigm to examine how perceptual sensitivity (d') and response times (RTs) were affected by a threatening stimulus.
Daniel Preciado +2 more
openaire +5 more sources
Biased signaling by endogenous opioid peptides. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance There are >20 different endogenous opioid peptides derived from the three precursors proopiomelanocortin, proenkephalin, and prodynorphin; a long-standing question is the biological utility of having this variety of peptides.
Gomes I +7 more
europepmc +6 more sources