Results 31 to 40 of about 187,893 (285)
Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases [PDF]
Nature CommunicationsAbstractActions are biased by the outcomes they can produce: Humans are more likely to show action under reward prospect, but hold back under punishment prospect. Such motivational biases derive not only from biased response selection, but also from biased learning: humans tend to attribute rewards to their own actions, but are reluctant to attribute ...
Algermissen, J +4 more
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Targeting the IGF-1R: The Tale of The Tortoise and The Hare
Frontiers in Endocrinology, 2015 The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and maintenance of cancer. Since the first links between growth factor receptors and oncogenes were noted over three decades ago, targeting the IGF-1R has been of
Caitrin eCrudden +3 more
doaj +1 more source
Accounting for Biases in the Estimation of Neuronal Signal Correlation [PDF]
The Journal of Neuroscience, 2021 Signal correlation (rs) is commonly defined as the correlation between the tuning curves of two neurons and is widely used as a metric of tuning similarity. It is fundamental to how populations of neurons represent stimuli and has been central to many studies of neural coding.
Dean A, Pospisil, Wyeth, Bair
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Frontiers in Synaptic Neuroscience, 2018 The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins.
Lani S. Chun +12 more
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Frontiers in Endocrinology, 2021 Anorexia Nervosa (AN) is a complex disease that impairs the metabolic, mental and physiological health of affected individuals in a severe and sometimes lethal way.
Mariam S. Khelifa +2 more
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Frontiers in Pharmacology, 2022 The δ-opioid receptor (δOR) has been considered as a therapeutic target in multiple neurological and neuropsychiatric disorders particularly as δOR agonists are deemed safer alternatives relative to the more abuse-liable µ-opioid receptor drugs. Clinical
Arryn T. Blaine +12 more
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Coordinated functional divergence of genes after genome duplication in Arabidopsis thaliana [PDF]
, 2017 Gene and genome duplications have been rampant during the evolution of flowering plants. Unlike small-scale gene duplications, whole-genome duplications (WGDs) copy entire pathways or networks, and as such create the unique situation in which such ...
De Smet, Riet +4 more
core +1 more source
Anxiety biases audiovisual processing of social signals
Behavioural Brain Research, 2021 In everyday life, information from multiple senses is integrated for a holistic understanding of emotion. Despite evidence of atypical multisensory perception in populations with socio-emotional difficulties (e.g., autistic individuals), little research to date has examined how anxiety impacts on multisensory emotion perception.
Naomi Heffer +4 more
openaire +2 more sources
The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
Frontiers in Pharmacology, 2021 Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function.
Yunlu Jiang +11 more
doaj +1 more source
FSHR Trans-Activation and Oligomerization
Frontiers in Endocrinology, 2018 Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women.
Kamila Szymańska +7 more
doaj +1 more source