Results 191 to 200 of about 187,893 (285)

How Ligands Achieve Biased Signaling toward Arrestins. [PDF]

Biochemistry
Jiang Q, Che T.
europepmc   +1 more source

IL-36α and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling. [PDF]

Biomedicines, 2021
Al-Luhaibi ZII, Dernovics Á, Seprényi G, Ayaydin F, Boldogkői Z, Veréb Z, Megyeri K.   +6 more
europepmc   +1 more source

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats [PDF]

, 2018
Bové, Calastretti, Carloni, Castedo, Castedo, Chauhan, Chen, Chong, Chong, Donnan, Ferri, Flynn, Fu, Genova, Harada, Hwang, Hwang, Jiang, Kofman, Koh, Li, Li, Lu, Lu, Maiese, Rieker, Sanghera, Santini, Schmued, Shahjouei, Siddiqui, Thyrell, Urbanek, Wang, Wang, Wechsler, Wong, Xie, Xie, Yang, Yin, Zare, Zeng   +42 more
core   +2 more sources

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Biased Signaling and Its Role in the Genesis of Short- and Long-Acting β₂-Adrenoceptor Agonists. [PDF]

Biochemistry
Phan NTN, Borrega-Roman L, Hoare BL, Harwood CR, Geary N, Guba W, Han Y, Zenko V, Koers EJ, Rufer AC, Grether U, Veprintsev DB, Sykes DA.   +12 more
europepmc   +1 more source

Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling. [PDF]

iScience, 2022
Gomez-Soler M, Gehring MP, Lechtenberg BC, Zapata-Mercado E, Ruelos A, Matsumoto MW, Hristova K, Pasquale EB.   +7 more
europepmc   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma. [PDF]

Cell Rep
Sadeghi M, Salama MF, Chiappone SB, Huang A, Resnick AE, Kandpal M, Clarke CJ, Haley JD, Davuluri RV, Hannun YA.   +9 more
europepmc   +1 more source

Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes. [PDF]

Int J Mol Sci, 2021
Delaitre C, Boisbrun M, Lecat S, Dupuis F.   +3 more
europepmc   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source