Results 201 to 210 of about 187,893 (285)

Kinome profiling: A veritable Rosetta Stone for protease-activated receptor 1 biased signaling. [PDF]

Vascul Pharmacol
Rajala R, Griffin CT.
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Biased Signaling Agonists of Dopamine D3 Receptor Differentially Regulate the Effects of Cocaine On Dopamine Transporter Function. [PDF]

ACS Chem Neurosci
Cohen SR, Xu W, Aziz NF, España RA, Kortagere S.   +4 more
europepmc   +1 more source

Carboxylic‐Acid Functionalized Multiwalled Carbon Nanotube‐Alkane‐Based Resistive Temperature Sensor for Cold Chain Applications

Advanced Engineering Materials, EarlyView.
This study presents a reversible temperature sensor with high switching ratio, ∼103. The device is fabricated using PET‐ITO and carbon nanotube dispersions in alkane. Considering its application in cold chain logistics, a proof‐of‐concept with LED is showcased. Thus, a temperature drop below the threshold temperature (crystallization temperature of the
Sunil Kumar Behera, Philippe Marrec, A. Jorge Parola, Madalena Dionísio, Hugo Águas, Andreia F. M. Santos, Hamed Pourkheirollah, Donald Lupo, César A. T. Laia   +8 more
wiley   +1 more source

Unconventional receptor functions and location-biased signaling of the lactate GPCR in the nucleus. [PDF]

Life Sci Alliance
Mohammad Nezhady MA, Cagnone G, Bajon E, Chaudhari P, Modaresinejad M, Hardy P, Maggiorani D, Quiniou C, Joyal JS, Beauséjour C, Chemtob S.   +10 more
europepmc   +1 more source

Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor. [PDF]

Nat Chem, 2022
Yen HY, Liko I, Song W, Kapoor P, Almeida F, Toporowska J, Gherbi K, Hopper JTS, Charlton SJ, Politis A, Sansom MSP, Jazayeri A, Robinson CV.   +12 more
europepmc   +1 more source

Planar Solid‐State Nanopores Toward Scalable Nanofluidic Integration Based on CMOS Technology

Advanced Engineering Materials, EarlyView.
We present a scalable silicon‐based fabrication strategy for planar solid‐state nanopores to enable their integration with complex nanofluidic systems. Prototype devices demonstrate normal voltage‐current characteristics, good noise performance, and appreciable streaming currents. Our CMOS‐compatible fabrication process offers precise geometric control
Ngan Hoang Pham, Chenyu Wen, Mohammad Hadi Khaksaran, Won‐Yong Lee, Javier Cruz, Klas Hjort, Dongping Wu, Shi‐Li Zhang   +7 more
wiley   +1 more source

Agonists of the Nuclear Receptor PPARγ Can Produce Biased Signaling. [PDF]

Mol Pharmacol
Rayl ML, Nemetchek MD, Voss AH, Hughes TS.   +3 more
europepmc   +1 more source

Prediction of Surface Topography Parameters in Direct Laser Interference Patterning of Stainless Steel Using Infrared Monitoring and Convolutional Neural Networks

Advanced Engineering Materials, EarlyView.
This study presents an infrared monitoring approach for direct laser interference patterning (DLIP) combined with a convolutional neural network (CNN). Thermal emission data captured during structuring are used to predict surface topography parameters.
Lukas Olawsky, Marcelo Sallese, Leander Kläber, Clemens Kuhn, Keming Du, Andrés Fabián Lasagni   +5 more
wiley   +1 more source

Advances in calcium-sensing receptor modulation: biased signaling and therapeutic potential. [PDF]

Signal Transduct Target Ther
Uhlmann L, Wagner U.
europepmc   +1 more source