Results 21 to 30 of about 230,113 (234)

Point-of-Care Testing to Differentiate Various Acid–Base Disorders in Chronic Kidney Disease

Diagnostics, 2023
Background: Normal-anion-gap metabolic acidosis (AGMA) and high-anion-gap metabolic acidosis (HAGMA) are two forms of metabolic acidosis, which is a common complication in patients with chronic kidney disease (CKD).
Tomasz Gołębiowski, Sławomir Zmonarski, Wiktoria Rożek, Mateusz Powązka, Patryk Jerzak, Maciej Gołębiowski, Mariusz Kusztal, Piotr Olczyk, Jakub Stojanowski, Krzysztof Letachowicz, Mirosław Banasik, Andrzej Konieczny, Magdalena Krajewska   +12 more
doaj   +1 more source

Therapeutic Interference With Vascular Calcification—Lessons From Klotho-Hypomorphic Mice and Beyond

Frontiers in Endocrinology, 2018
Medial vascular calcification, a major pathophysiological process associated with cardiovascular disease and mortality, involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs).
Florian Lang, Christina Leibrock, Christina Leibrock, Lisann Pelzl, Meinrad Gawaz, Burkert Pieske, Burkert Pieske, Burkert Pieske, Ioana Alesutan, Ioana Alesutan, Ioana Alesutan, Jakob Voelkl, Jakob Voelkl   +12 more
doaj   +1 more source

Measurements of Bicarbonate in Water Containing Ocean-Level Sulfate Using a Simple Multi-Pass Optical Raman System

Oceans, 2021
The concentration of dissolved inorganic carbon in the oceans at depths of a few meters to thousands of meters is a critical parameter for understanding global warming. The concentration is both pH dependent and depth dependent.
Chetan Shende, Stuart Farquharson, Duncan Farquharson, Carl Brouillette   +3 more
doaj   +1 more source

Airway epithelial cells: ‘Bicarbonate in’≠‘Bicarbonate out’

The Journal of Physiology, 2012
The importance of intracellular and extracellular pH to physiological function is unquestioned. There are few scenarios in which pathological processes do not include aberrant pH. For example, cystic fibrosis, a genetic disease that adversely affects airways and other epithelia throughout the body, is associated with secretions that have abnormally low
openaire   +3 more sources

Tetraethylammonium bicarbonate trihydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C(8)H(20)N(+)·CHO(3) (-)·3H(2)O, the bicarbon-ate anion, which has a small mean deviation from the plane of 0.0014 Å, fully utilises its three O and one H atom to form various O-H⋯O hydrogen bonds with the three water mol-ecules in the asymmetric unit, generating a hydrogen-bonded layer, which extends along (10[Formula: see text])
Heping Li, Yimin Hou, Yunxia Yang
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Relationship between baseline bicarbonate and 30-day mortality in patients with non-traumatic subarachnoid hemorrhage

Frontiers in Neurology
ObjectiveThis study aimed to explore the relationship between baseline bicarbonate levels and 30-day mortality in individuals with non-traumatic subarachnoid hemorrhage (SAH).MethodsPatients with non-traumatic SAH were chosen from the Medical Information
Wenyuan Du, Jingmian Yang, Yanfang Lou, Jiahua You, Qiang Wang   +4 more
doaj   +1 more source

Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Kidney Research and Clinical Practice, 2020
Background : Few studies have investigated the relationship between serum total carbon dioxide (CO2) concentration and bicarbonate ion (HCO3-) concentration in patients undergoing hemodialysis.
Keiji Hirai, Susumu Ookawara, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Kiyonori Ito, Yuichirou Ueda, Tatsuro Watano, Shinji Fujino, Kiyoka Omoto, Yoshiyuki Morishita   +16 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source