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Molecular arrangement and modulation of extrasynaptic αβδ GABA<sub>A</sub> receptors. [PDF]
Nestorow SA +16 more
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Gain and loss of function changes in CACNA1C affect neuronal networks through divergent pathways
Wilkinson G +5 more
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Electroencephalographic effects of bicuculline
Physiology and Behavior, 1972Abstract The effects of bicuculline on the electrical activity of various sites of the cerebro-spinal axis have been studied in the rabbit and in the rat. Bicuculline induces electroencephalographic patterns very similar to that of picrotoxin and pentamethylenetetrazol and distinct from that induced by strychnine.
V G Longo
exaly +3 more sources
Neurology, 1981
The convulsant bicuculline (BICUC) had both synaptic and nonsynaptic actions on mouse spinal cord neurons in primary dissociated cell culture. BICUC antagonized postsynaptic responses to the inhibitory neurotransmitter GABA (a synaptic action) and produced direct membrane depolarization by blocking a membrane potassium conductance and directly ...
E J, Heyer, L M, Nowak, R L, Macdonald
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The convulsant bicuculline (BICUC) had both synaptic and nonsynaptic actions on mouse spinal cord neurons in primary dissociated cell culture. BICUC antagonized postsynaptic responses to the inhibitory neurotransmitter GABA (a synaptic action) and produced direct membrane depolarization by blocking a membrane potassium conductance and directly ...
E J, Heyer, L M, Nowak, R L, Macdonald
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Bicuculline and thalamic inhibition
Experimental Brain Research, 1972A study was made of the effects of electrophoretically administered bicuculline on the recurrent inhibition of thalamo-cortical relay neurones of the ventrobasal complex and the dorsal lateral geniculate nucleus of decerebrate and anaesthetised cats (pentobarbitone sodium). Electrophoretically administered glycine, GABA and taurine depressed the firing
D R, Curtis, A K, Terbécis
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Bicuculline epileptogenesis in the rat
Brain Research, 1984Bicuculline has been applied electrophoretically from a fluid filled microelectrode at different depths within the primary somatosensory area of the cerebral cortex of rats anaesthetized with urethane. The delay between onset of drug application at a constant rate and onset of spontaneous focal interictal epileptiform discharges (FIEDs), detected by a ...
A M, Campbell, O, Holmes
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Bicuculline Methochloride as a GABA Antagonist
Nature New Biology, 1972THE convulsant phthalide isoquinoline alkaloid bicuculline1 has proved valuable in studying inhibitory processes in the mammalian central nervous system mediated by γ-aminobutyric acid (GABA). When administered electrophoretically near single neurones, bicuculline selectively reduces the inhibitory effect of GABA, with little or no reduction of the ...
G A, Johnston +5 more
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Bicuculline insensitive effects of baclofen
Naunyn-Schmiedeberg's Archives of Pharmacology, 1983The action of bicuculline on the effect of baclofen and muscimol were investigated in behavioural, biochemical and binding studies in rats. Both (+/-)-baclofen (5 mg kg-1 i.p.) and muscimol (1.4 mg kg-1 i.p.) decreased motor activity and aggressiveness.
L K, Rägo, A M, Zarkovsky
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Effects of bicuculline on central inhibition
Neuropharmacology, 1972Abstract The effects of the specific gamma aminobutyric acid (GABA) antagonist bicuculline were investigated on direct, presynaptic and reticular inhibition and cerebellar disfacilitation of the segmental monosynaptic action potentials of decerebrate cats.
R D, Huffman, L S, McFadin
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