Results 111 to 120 of about 13,955 (172)

Molecular arrangement and modulation of extrasynaptic αβδ GABA<sub>A</sub> receptors. [PDF]

open access: yesNat Commun
Nestorow SA   +16 more
europepmc   +1 more source
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Electroencephalographic effects of bicuculline

Physiology and Behavior, 1972
Abstract The effects of bicuculline on the electrical activity of various sites of the cerebro-spinal axis have been studied in the rabbit and in the rat. Bicuculline induces electroencephalographic patterns very similar to that of picrotoxin and pentamethylenetetrazol and distinct from that induced by strychnine.
V G Longo
exaly   +3 more sources

Bicuculline

Neurology, 1981
The convulsant bicuculline (BICUC) had both synaptic and nonsynaptic actions on mouse spinal cord neurons in primary dissociated cell culture. BICUC antagonized postsynaptic responses to the inhibitory neurotransmitter GABA (a synaptic action) and produced direct membrane depolarization by blocking a membrane potassium conductance and directly ...
E J, Heyer, L M, Nowak, R L, Macdonald
openaire   +2 more sources

Bicuculline and thalamic inhibition

Experimental Brain Research, 1972
A study was made of the effects of electrophoretically administered bicuculline on the recurrent inhibition of thalamo-cortical relay neurones of the ventrobasal complex and the dorsal lateral geniculate nucleus of decerebrate and anaesthetised cats (pentobarbitone sodium). Electrophoretically administered glycine, GABA and taurine depressed the firing
D R, Curtis, A K, Terbécis
openaire   +2 more sources

Bicuculline epileptogenesis in the rat

Brain Research, 1984
Bicuculline has been applied electrophoretically from a fluid filled microelectrode at different depths within the primary somatosensory area of the cerebral cortex of rats anaesthetized with urethane. The delay between onset of drug application at a constant rate and onset of spontaneous focal interictal epileptiform discharges (FIEDs), detected by a ...
A M, Campbell, O, Holmes
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Bicuculline Methochloride as a GABA Antagonist

Nature New Biology, 1972
THE convulsant phthalide isoquinoline alkaloid bicuculline1 has proved valuable in studying inhibitory processes in the mammalian central nervous system mediated by γ-aminobutyric acid (GABA). When administered electrophoretically near single neurones, bicuculline selectively reduces the inhibitory effect of GABA, with little or no reduction of the ...
G A, Johnston   +5 more
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Bicuculline insensitive effects of baclofen

Naunyn-Schmiedeberg's Archives of Pharmacology, 1983
The action of bicuculline on the effect of baclofen and muscimol were investigated in behavioural, biochemical and binding studies in rats. Both (+/-)-baclofen (5 mg kg-1 i.p.) and muscimol (1.4 mg kg-1 i.p.) decreased motor activity and aggressiveness.
L K, Rägo, A M, Zarkovsky
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Effects of bicuculline on central inhibition

Neuropharmacology, 1972
Abstract The effects of the specific gamma aminobutyric acid (GABA) antagonist bicuculline were investigated on direct, presynaptic and reticular inhibition and cerebellar disfacilitation of the segmental monosynaptic action potentials of decerebrate cats.
R D, Huffman, L S, McFadin
openaire   +2 more sources

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