Results 121 to 130 of about 13,955 (172)

Picrotoxin-like action of bicuculline

European Journal of Pharmacology, 1972
Abstract In cats anesthetized with nembutal, bicuculline reduced the cuneate surface positive wave, the dorsal column reflex and the increase in excitability of cuneate presynaptic terminals after conditioning stimulation. These effects are similar to those of picrotoxin and indicate a reduction in presynaptic inhibitory action across the dorsal ...
N R, Banna, A, Naccache, S J, Jabbur
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Evaluation of Bicuculline as a GABA Antagonist

Nature, 1971
THERE has been controversy recently about the reliability of bicuculline as an antagonist of the putative inhibitory transmitter γ-aminobutyric acid (GABA) in the brain1–3. Although the effects of bicuculline have so far been explained in terms of its combination with the GABA receptor, bicuculline might also affect the removal processes for GABA and ...
D W, Straughan, M J, Neal, M A, Simmonds, G G, Collins, R G, Hill   +4 more
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Bicuculline and Central GABA Receptors

Nature, 1970
WE are unable to accept the implication by Krnjevic and his associates1 that we erred in reporting2 bicuculline to be a relatively specific antagonist of γ-aminobutyric acid (GABA) in the central nervous system of the cat.
D R, Curtis, A W, Duggan, D, Felix, G A, Johnston   +3 more
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GABA, Bicuculline and Central Inhibition

Nature, 1970
The central nervous action of the alkaloid bicuculline provides pharmacological evidence that GABA is likely to be a transmitter at certain inhibitory synapses.
D R, Curtis, A W, Duggan, D, Felix, G A, Johnston   +3 more
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Intracerebral site of convulsant action of bicuculline

Life Sciences, 1985
Bicuculline was injected intracerebrally in several forebrain sites of the rat. In a discrete area in the vicinity of prepiriform cortex, a single, unilateral injection of bicuculline (49 pmol) produced generalized clonic seizures documented behaviorally and electroencephalographically.
S, Piredda, C R, Lim, K, Gale
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Depression of postejaculatory ultrasonic vocalization by (+)-bicuculline

Behavioural Brain Research, 1986
The male rat emits ultrasonic (22 kHz) vocalizations after ejaculation and behavioural and electrophysiological evidence suggests that this vocalization reflects an inhibitory state underlying and determining the postejaculatory refractory period (PEI).
A, Fernández-Guasti, K, Larsson, J, Vega-Sanabria   +2 more
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Bicuculline

2000
Abstract A Ion channel dysfunction (GABA chloride-channel agonist) A Seizure disorder (acute administration) Bicuculline is a naturally occuring convulsant phthalide iso quinoline alkaloid from Dutchman’s breeches (Dicentra cu cullaria), Adlumia fungosa, Fumariaceae, and Corydalis spp.
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Differential blockade of bicuculline convulsions by neuroleptics

European Journal of Pharmacology, 1978
Haloperidol, pimozide, sulpiride and metoclopramide blocked bicuculline-induced convulsions in mice. Chlorpromazine and thioridazine exhibited this effect at low doses whereas at higher doses (e.g. 1 mg/kg i.p. chlorpromazine) this activity was no longer apparent.
P, Worms, K G, Lloyd
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Bicuculline and neuronal activity in motor cortex

Electroencephalography and Clinical Neurophysiology, 1980
We have studied the effects of bicuculline applied in microgram quantities to the precruciate gyrus (motor cortex) of cat upon visually evoked and spontaneous single-unit and slow-wave activity. The bicuculline produced an increase in both the visually evoked and the spontaneous unit activity.
J D, Glass, G H, Fromm, A S, Chattha
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Effects of bicuculline on inspiratory activities in piglets

Brain Research, 1994
Antagonism of the alpha receptor sub-type at gamma-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABAA receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes.
A M, Steele, Z A, Siddiqi, A L, Sica
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