Results 81 to 90 of about 50,394 (243)

Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model

Frontiers in Cardiovascular Medicine, 2022
Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. Although different molecular players and etiological factors (genetic and hemodynamic) have been suggested ...
María Teresa Soto-Navarrete, María Teresa Soto-Navarrete, Bárbara Pozo-Vilumbrales, Bárbara Pozo-Vilumbrales, Miguel Ángel López-Unzu, Miguel Ángel López-Unzu, Miguel Ángel López-Unzu, Carmen Rueda-Martínez, M. Carmen Fernández, M. Carmen Fernández, M. Carmen Fernández, Ana Carmen Durán, Ana Carmen Durán, Francisco Javier Pavón-Morón, Francisco Javier Pavón-Morón, Francisco Javier Pavón-Morón, Jorge Rodríguez-Capitán, Jorge Rodríguez-Capitán, Jorge Rodríguez-Capitán, Borja Fernández, Borja Fernández, Borja Fernández   +21 more
doaj   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Point on the Aortic Bicuspid Valve

Life, 2022
Background—Bicuspid aortic valve (BAV) disease is the most prevalent congenital heart disease in the world. Knowledge about its subtypes origin, development, and evolution is poor despite the frequency and the potential gravity of this condition.
Chloé Bernard, Marie Catherine Morgant, David Guillier, Nicolas Cheynel, Olivier Bouchot   +4 more
doaj   +1 more source

Novel Phenotypes in Bicuspid Aortic Valve Disease

, 2011
Bicuspid aortic valve (BAV) is the most common congenital abnormality of the human heart, affecting approximately 1-2% of the general population (Williams, 2006). It is widely accepted that BAV is a very heterogeneous disease and that the different phenotypes of BAV disease may be caused by unique pathogenetic mechanisms.
Girdauskas, Evaldas, A., Michael, Kuntze, Thomas   +2 more
openaire   +4 more sources

Fetal Diagnosis of Hypoplastic Left Heart Syndrome With Restrictive Atrial Septum—Atrial Septal Morphology, Associated Lung Disease and Outcomes

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Fetuses with hypoplastic left heart syndrome (HLHS) and restrictive/intact atrial septum (RAS) have high mortality, partly due to pulmonary lymphangiectasia (PL). This study aimed to characterize atrial septal morphology in fetuses with HLHS and RAS and evaluate the impact of fetal intervention on PL and outcomes.
Sofie Dannesbo, Gloria Ho, Mike Seed, Vitor Guerra, Rajiv Chaturvedi, Andrew C. Cook, Niels Vejlstrup, Kasper Iversen, Henning Bundgaard, Lindsay R. Freud   +9 more
wiley   +1 more source

Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis

Precision Medical Sciences, EarlyView.
Central illustration: Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement. Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis.
Muhammad Huzaifa Ahmed Khan, Muneeb Khawar, Asad Ullah Farooq, Azooba Khalid, Syed Muhammad Ahsan, M. Hamza Naseer Awan, Muhammad Soban Nisar, Asim Elahi, Muhammad Aqib Faizan, Iqra Shahid, Abdullah Munir Ahmed, Faseeh Haider, Rejina Chhetri   +12 more
wiley   +1 more source

Thoracic Aortic Aneurysm Growth Rates and Predicting Factors: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Thoracic aortic aneurysm (TAA) is an indolent, potentially fatal disease, which progresses at variable rates that are influenced by pathogenesis and patient characteristics.
Matthew Henry, Carlos A. Campello Jorge, Pieter A.J. van Bakel, Heather A. Knauer, Mark MacEachern, Joost A. van Herwaarden, Gisela Teixidó‐Tura, Arturo Evangelista, Richmond W. Jeremy, C. A. Figueroa, Himanshu J. Patel, Marion Hofmann Bowman, Kim Eagle, Nicholas S. Burris   +13 more
doaj   +1 more source

Marfan Syndrome Versus Bicuspid Aortic Valve Disease: Comparative Analysis of Obstetric Outcome and Pregnancy-Associated Immediate and Long-Term Aortic Complications

Journal of Clinical Medicine, 2020
Pregnancy poses a threat to women with aortopathy. Conclusive data on the obstetric and aortic outcome in this risk collective, especially when it comes to aortic complications in the long term, are still missing. This study offers a comparative analysis
B. Toprak, K. Szöcs, E. Zengin-Sahm, C. Sinning, Amra Hot, P. Bannas, K. Hecher, B. Hüneke, T. Mir, M. Rybczynski, E. Girdauskas, S. Blankenberg, Y. von Kodolitsch   +12 more
semanticscholar   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Transcatheter Treatment of Bicuspid Aortic Valve Stenosis: From Observational Studies to Randomized Clinical Trials

Structural Heart
Bicuspid aortic valve (BAV) disease is the most common congenital heart abnormality, which affects up to 2% of the population and significantly increases the lifetime risk of aortic stenosis and the need for valve replacement. While surgical aortic valve
Daryoush Samim, MD, Matthias Siepe, MD, Peter Jüni, MD, Aakriti Gupta, MD, Hasan Jilaihawi, MD, Michael A. Borger, MD-PhD, Raj R. Makkar, MD, Martin B. Leon, MD, Stephan Windecker, MD   +8 more
doaj   +1 more source