Results 81 to 90 of about 49,147 (254)

T‐Shaped Stibenium(III) Cation: Hydrostibination Without Sb─H Bond

open access: yesAngewandte Chemie, EarlyView.
A cationic, structurally constrained stibenium platform mediates anti‐Markovnikov hydrostibination of alkenes via element–ligand cooperativity (ELC), thereby bypassing the need for weak Sb─H bonds. ABSTRACT The hydrostibination of alkenes represents a largely underdeveloped transformation, owing to the intrinsic lability of the required Sb─H reagents ...
Ekta Nag   +4 more
wiley   +2 more sources

Borylcyclopropanes: Synthetic Strategies and Applications

open access: yesAngewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Thermal/Mechanical Measurement and Modeling of Bicycle Disc Brakes

open access: yesProceedings, 2018
Brake induced heating has become more difficult to control as bicycle component mass has been reduced. High-power braking with insufficient cooling or thermal capacitance can create excessive temperatures, boiling brake fluid, performance degradation ...
Ioan Feier, Robin Redfield
doaj   +1 more source

Modular Access to α‐Tertiary Amines: Electrochemical Tandem Di‐Functionalization of Olefins With Ammonia Surrogates and Amino Acids

open access: yesAngewandte Chemie, EarlyView.
A metal‐ and oxidant‐free electrochemical multicomponent di‐functionalization strategy that rapidly converts 1,1‐disubstituted alkenes into α‐tertiary primary amines with simultaneous installation of bio‐relevant sulfur or selenium motifs was devised for late‐stage functionalization. ABSTRACT Quaternary carbon centers, especially those bearing nitrogen,
Adrija Ghosh   +4 more
wiley   +2 more sources

Urban Cycling as an Indicator of Socio-Economic Innovation and Sustainable Transport

open access: yesQuaestiones Geographicae, 2018
Environmental pollution in cities is an increasingly popular issue tackled in research. One of the elements with a significant impact on the state of urban ecosystems is transport with its pressure on individual components of the environment. Sustainable
Kwiatkowski Michał Adam
doaj   +1 more source

888 An integrative approach to optimize a synthetic EphA2/CD137 agonist: balancing potency, physiochemical properties, and pharmacokinetics to achieve robust anti-tumor activity

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Kristen Hurov   +9 more
doaj   +1 more source

826 Establishing the preclinical/translational PK/PD relationship for BT7480, a nectin-4/CD137 Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Kristen Hurov   +6 more
doaj   +1 more source

2 Quantitation of CD137 and Nectin-4 expression across multiple tumor types to support indication selection for BT7480, a Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Mate Nagy   +14 more
doaj   +1 more source

Elite performance in para-cycling: A scoping review

open access: yesEuropean Journal of Adapted Physical Activity
Elite para-cycling needs an overview of relevant and valid research to better understand and improve performance and to develop the sport, using evidence-based decision making.
Albert Smit   +5 more
doaj   +1 more source

The epidemiologic characteristic of accidents and injuries in Two-wheeled vehicle rider in Jahrom city from 2009-2014.

open access: yesفصلنامه دانشگاه علوم پزشکی جهرم, 2018
Introduction: The Accident is an event that causes damage to be detected. Increasing in traffic accidents threaten the community health promotion. Physical, financial and psychological disadvantages of accident are essential to invest a public health ...
fajrieh Zahedinia   +4 more
doaj  

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