Results 61 to 70 of about 49,147 (254)

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Looking back on childhood experiences of homelessness: Stories of ongoing residential instability and resilience

American Journal of Community Psychology, EarlyView.
Abstract Families' experience of homelessness is typically examined from the perspective of parents during or shortly after a shelter stay. Parents complain about rules, surveillance, crowding, and challenges to parenting in both homeless shelters and in doubling up with other households (sharing the others' homes), and relief when they attain their ...
Marybeth Shinn, Emma J. Sacks, Kayla Fike   +2 more
wiley   +1 more source

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

Angewandte Chemie, EarlyView.
Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley   +2 more sources

A Sociological Analysis of the Relationship between Attitude towards Bicycle and Using Bicycle in Short Trips in Isfahan

جامعه شناسی کاربردی, 2013
Introduction Unstructured use of motor vehicles has created many social problems especially in large cities. Heavy traffic, fatal accidents, obesity and less mobility, voice pollution, air pollution, physical harms such as headache, eye sting ...
Siroos Ahmadi, Ali Heidari, Asghar Mirfardi, Zahra Mardani   +3 more
doaj  

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source

Flavin Catalysts in Organic Synthesis

Angewandte Chemie, EarlyView.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

The effect of different type of exercises on the isokinetic strength of quadriceps and hamstring muscles

Türk Spor ve Egzersiz Dergisi, 2017
This study was conducted with the aim of investigating the effect of three different types of exercise on the isokinetic strength of quadriceps and hamstring muscles.
Alpaslan Gorucu, Bekir Tokay
doaj  

‘Bike-share-and-ride’ users: who they are and what they think of travelling to rail and bus public transport hubs

Prace Komisji Geografii Przemysłu Polskiego Towarzystwa Geograficznego
The bicycle has successfully emerged in recent years as a promising alternative to the motorised transport that dominates cities. It also plays a pronounced role in multimodal mobility when combining cy- cling and public transport using the bike and ...
Michał Kwiatkowski
doaj   +1 more source

Early Endoscopic Repair of Traumatic Skull Base Dural Injuries: Challenging the Dogma of Conservative Management

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Traditional management of traumatic skull base dural injury has often favored observation and conservative therapy, despite the risk of delayed intracranial complications. This paradigm originated when operative intervention required craniotomy and carried significant morbidity.
Jessica W. Grayson, Madeline P. Bald, Lauren McLeod, Adam J. Skelton, Nicolaus D. Knight, Do‐Yeon Cho, Justin Turner, Hari Jeyarajan, Kristen O. Riley, Bradford A. Woodworth   +9 more
wiley   +1 more source

Reactions of Terminal Olefins With Iron Carbenes

Angewandte Chemie, EarlyView.
Iron carbenes react with terminal olefins and show productive metathesis or metathesis‐divergent pathways depending on the nature of the olefin. Reactions proceed through 2π + 2π cycloadditions to generate transient metallacyclobutane intermediates that undergo cycloreversion to generate the metathesis product or the metathesis‐divergent β‐hydride ...
Zachary S. Lincoln, Melissa R. Hoffbauer, Vlad M. Iluc   +2 more
wiley   +2 more sources