Results 71 to 80 of about 28,403 (287)

Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent

Molecules
AUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide’s superior antiproliferative ...
Julie Vatté, Véronique Bourdeau, Gerardo Ferbeyre, Andreea R. Schmitzer   +3 more
doaj   +1 more source

Determination of polyhexamethylene biguanide hydrochloride

Reviews in Analytical Chemistry, 2014
Polyhexamethylene biguanide hydrochloride (PHMB-HCl) is widely used as a disinfectant in personal care products such as cosmetics and toiletries and as a sanitizer in swimming pools. PHMB-HCl possesses marked characteristics of cationic polyelectrolytes.
Masadome Takashi, Hattori Toshiaki
doaj   +1 more source

Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis

Case Reports in Ophthalmology, 2011
Aims: To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment.
Giulio Ferrari, Stanislav Matuska, Paolo Rama   +2 more
doaj   +1 more source

Metformin attenuates metabolic insulin sensitivity and insulin‐stimulated carbohydrate oxidation after high‐intensity exercise training in adults at risk for metabolic syndrome

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Mixed evidence exists on whether metformin adds to or attenuates the insulin‐sensitising effects of exercise. To date, no studies have tested whether metformin differentially impacts exercise training intensity–mediated insulin sensitivity.
Steven K. Malin, Emily M. Heiston, Daniel J. Battillo, Tristan J. Ragland, Anna Ballantyne, Sue A. Shapses, Ankit M. Shah, James T. Patrie   +7 more
wiley   +1 more source

Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges [PDF]

, 2016
The development and strategic application of effective anticancer therapies have turned out to be one of the most critical approaches of managing human cancers. Nevertheless, drug resistance is the major obstacle for clinical management of these diseases
Al Rawahi, Chen, Chiampanichayakul, Coughlan, David W. Chan, Dilman, Elit, Gilani, Gui, Hextan Y.S. Ngan, Holmes, Kikkawa, Kuhajda, Leung, Li, Mingo M.H. Yung, Odunsi, Pitchakarn, Rose, Rosenblum, Sanchez-Cespedes, Singh   +21 more
core   +1 more source

Effect of Local Administration of Meglumine Antimoniate and Polyhexamethylene Biguanide Alone or in Combination with a Toll-like Receptor 4 Agonist for the Treatment of Papular Dermatitis due to Leishmania infantum in Dogs [PDF]

, 2023
Icíar Martínez-Flórez, Maria Jose Guerrero, Annabel Dalmau, Maria Cabré, M. Magdalena Alcover, Diana Berenguer, Liam Good, Roser Fisa, Cristina Riera, Laura Ordeix, Laia Solano‐Gallego   +10 more
openalex   +1 more source

SGLT2 inhibitors and mortality in older adults with diabetic kidney disease: A target trial emulation study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Randomized controlled trials on sodium‐glucose cotransporter 2 (SGLT2) inhibitors have yielded inconsistent findings regarding mortality benefits. It remains unclear whether, and in which subgroups, SGLT2 inhibitors confer survival benefits in older adults with diabetic kidney disease (DKD).
Tatsuhiko Azegami, Hidehiro Kaneko, Akira Okada, Yuta Suzuki, Toshiyuki Ko, Kazuki Aoyama, Takashin Nakayama, Yuya Kimura, Katsuhiko Fujiu, Norifumi Takeda, Hiroyuki Morita, Takashi Yokoo, Koichi Node, Masaomi Nangaku, Norihiko Takeda, Hideo Yasunaga, Kaori Hayashi   +16 more
wiley   +1 more source

Biguanides in combination with olaparib limits tumorigenesis of drug‐resistant ovarian cancer cells through inhibition of Snail

Cancer Medicine, 2020
Ovarian cancer is the most lethal gynecological malignancy. Currently, new chemotherapeutic strategies are required to improve patient outcome and survival.
Qiong Wang, Vanessa M. López‐Ozuna, Tahira Baloch, Joanne Bithras, Oreekha Amin, Roy Kessous, Liron Kogan, Ido Laskov, Amber Yasmeen   +8 more
doaj   +1 more source

Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin [PDF]

, 2011
Aims/hypothesis Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of ...
A Dejgaard, AS Fauci, B. H. Ch. Stricker, BH Stricker, CH Chang, CJ Currie, D Mayer, D Mayer, D Simon, E Friberg, E Giovannucci, E Mannucci, Emerging Risk Factors Collaboration, H. R. Haak, HC Gerstein, HM Colhoun, J Rosenstock, J. W. W. Coebergh, JA Johnson, JM Jonasson, K Rothman, KL Edwards, L. E. Visser, LG Hemkens, LV Poll-Franse van de, M. P. P. van Herk-Sukel, MM Hassan, N Morden, P Kurtzhals, P Vigneri, P. H. Geelhoed-Duijvestijn, PD Home, R Huxley, R. M. C. Herings, R. Ruiter, S Bonovas, S Hernandez-Diaz, S Suissa, S. M. J. M. Straus, SC Larsson, SC Larsson, SC Larsson, SE Kahn, SJ Pocock, SL Bowker, SS Coughlin, U Smith, VA Grote, X Yang, YX Yang   +49 more
core   +5 more sources

Predictors of glycemic control with imeglimin for type 2 diabetes: Results of machine learning analyses using clinical trial data

Journal of Diabetes Investigation, EarlyView.
Identifying patient characteristics predictive of treatment response is crucial for optimizing type 2 diabetes outcomes. Using data from three phase 2/3 imeglimin trials in Japan, this analysis applied machine learning to determine characteristics associated with HbA1c improvement.
Katsuhiko Hagi, Kazumasa Yoshida, Hirotaka Watada, Kohei Kaku, Kohjiro Ueki   +4 more
wiley   +1 more source