Results 91 to 100 of about 15,321 (234)

Biguanides enhance antifungal activity against Candida glabrata

open access: yesVirulence, 2018
Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a challenge.
Shuying Xu   +13 more
doaj   +1 more source

ROLE FAILURE CORRECTION OF 25(OH)D IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

open access: yesБюллетень сибирской медицины, 2015
Objective. To estimate the correction failure 25 (OH) D in patients with polycystic ovary syndrome.Material and Methods. The study involved 44 patients with polycystic ovary syndrome, aged 31.32 ± 5.05, who were randomly assigned to 2 groups: 1st ...
M. V. Matveyeva   +4 more
doaj   +1 more source

Targeting redox alterations and sensors in colorectal cancer [PDF]

open access: yes
Biguanides are a class of antidiabetic drugs known for their anticancer properties, but their mechanism of action is still poorly understood. The most widely accepted model links biguanides antitumoral activity to the inhibition of Complex I of ...
RIPA, SILVIA
core  

Effects of biguanides on oxidative phosphorylation [PDF]

open access: yesCancer & Metabolism, 2014
Metformin, and the related biguanides buformin and phenformin, have been proposed to act by inhibiting respiratory complex I, causing the cellular energetic stress that activates AMP-kinase and initiates a multitude of cell-lineage-specific effects, including inhibition of gluconeogenesis in hepatocytes.
openaire   +2 more sources

Amlodipine and valsartan improving effect on the survival rate and deleterious pathological changes in streptozotocin-induced diabetic rats treated with metformin

open access: yesPharmaceutical and Biomedical Research, 2019
Diabetes mellitus (DM) and hypertension usually co-exist, and when this happens, the prognosis would be worse than each disease alone. Given this, we evaluated the possible effects of valsartan and amlodipine administration on metformin-treated diabetic ...
Israel Olapeju Bolanle   +2 more
doaj  

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