Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis
Animal Models and Experimental Medicine, EarlyView.This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding +10 more
wiley +1 more source
Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea. [PDF]
GutBannon CA +14 more
europepmc +1 more source
Bile acids are indispensable molecules that are needed for the absorption of fat and fat soluble vitamins. They are synthesized in the liver, excreted in the intestine where they perform their absorptive function, are reabsorbed and transported back to the liver thereby completing the enterohepatic cycle. Synthesis of bile acids is needed to compensate
Ferdinandusse, Sacha, Vaz, Frédéric M.
openaire +2 more sources
Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats
Animal Models and Experimental Medicine, EarlyView.Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček +3 more
wiley +1 more source
Ileal bile acid transporter inhibitors for chronic constipation in the elderly. [PDF]
World J Gastrointest Pharmacol TherAneesh PSR +4 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong +5 more
wiley +1 more source
Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity
Advanced NanoBiomed Research, EarlyView.Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu +4 more
wiley +1 more source
Bile Acid Sequestration Attenuates Desulfovibrio-Induced Hepatic Injury. [PDF]
MicroorganismsYang S +6 more
europepmc +1 more source
Analysis &Sensing, EarlyView.Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann +5 more
wiley +1 more source
Bile Acid Analogs with Anti-Germination Activities for Prophylaxis of <i>Clostridioides difficile</i> Infection Alter Bile Acid Homeostasis in the Enterohepatic Cycle. [PDF]
BiomoleculesVakeesan N +9 more
europepmc +1 more source