Results 111 to 120 of about 391,701 (312)

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids [PDF]

, 2019
A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate with highly adapted and ...
Mazmanian, Sarkis, Quinn, Robert A., Thron, Taren   +2 more
core  

Alteration of serum bile acids in non-small cell lung cancer identified by a validated LC–MS/MS method [PDF]

, 2023
Tongxin Yin, Ke Liu, Ying Shen, Yi Wang, Qiankun Wang, Tingting Long, Jiaoyuan Li, Liming Cheng   +7 more
openalex   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Comprehensive Analysis of Bile‐derived Medicinal Materials Based on Ultra‐High‐Performance Liquid Chromatography Coupled With Charged Aerosol Detection and Chemometrics

Analytical Science Advances
The medicinal use of bile‐derived materials dates back thousands of years. However, due to their complex origins and morphological similarities, adulteration of expensive bile types with cheaper alternatives remains prevalent in the market, significantly
Haonan Wu, Xianrui Wang, Fangliang He, Xianlong Cheng, Wenguang Jing, Feng Wei, Tian Yin   +6 more
doaj   +1 more source

Isolation and identification of bile salts conjugated with cysteinolic acid from bile of the red seabream, Pagrosomus major.

Journal of Lipid Research, 1991
Bile salts present in gallbladder of wild and cultured red seabream, Pagrosomus major, a marine teleost were analyzed. The bile from wild red seabream was found to contain two previously unknown bile salts along with two known bile salts, taurocholate ...
M Une, T Goto, K Kihira, T Kuramoto, K Hagiwara, T Nakajima, T Hoshita   +6 more
doaj   +1 more source

Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women [PDF]

, 2018
Microbiota and bile acids in the gastrointestinal tract profoundly alter systemic metabolic processes. In obese subjects, gradual weight loss ameliorates adipose tissue inflammation and related systemic changes. We assessed how rapid weight loss due to a
A Cotillard, A Damms-Machado, A Mardinoglu, A Wahlstrom, AC Vaughn, Adele Costabile, Alexandros Pechlivanis, AP Liou, AW Janssen, B Cariou, BE Lopez-Contreras, BJ Callahan, C Jiang, C Lozupone, CB Newgard, CD Simoes, D Festi, D McDonald, DP Faith, E Le Chatelier, ED Sonnenburg, F Ottosson, H Roytio, HK Pedersen, JA Holt, Jan L. Breslow, Jeanne M. Walker, JG Caporaso, JH Bottin, JJ Faith, JK Goodrich, JM Ridlon, JM Ridlon, JO Alemán, Joel Correa De Rosa, Jonathan R. Swann, José O. Alemán, JR Swann, JR Swann, K Katoh, KK Ryan, LA David, LM Cox, LM Nelson, M Lopez-Siles, M Monirujjaman, MA Stanislawski, Martin J. Blaser, MC Dao, MD Jensen, MH Sarafian, MJ Anderson, MN Price, NA Bokulich, NA Bokulich, NA Bokulich, Nicholas A. Bokulich, O Beckonert, P Elliott, P Lefebvre, Peter R. Holt, PH Bisschop, PJ Turnbaugh, R Kohli, R Liu, R Mathur, RA Haeusler, RC Pires, RE Ley, RO Kamrath, RR Henry, S Fiorucci, S Pendyala, SI Sayin, T Li, T Lundasen, T Sen, Thomas Battaglia, TN Kelly, Yupu Liang, ZD Fu   +80 more
core   +3 more sources

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source

724: Effect of fasting versus postprandial state on total bile acid levels in pregnancy [PDF]

, 2019
Devin D. Smith, Miranda K. Kiefer, Alan J. Lee, Sarah B. Davis, Taryn Summerfield, Mark B. Landon, Kara M. Rood   +6 more
openalex   +1 more source

Maternal and Foetal Outcomes in Early and Late Intrahepatic Cholestasis of Pregnancy and their Association with Maternal Serum Bile Acid Levels: A Prospective Cohort Study

, 2022
Sangeeta Gupta, Shreya Bhattarai, Taru Gupta, Sarika Arora   +3 more
openalex   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source