Results 51 to 60 of about 391,701 (312)

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is unknown.
Anne S. Henkel, Brian LeCuyer, Shantel Olivares, Richard M. Green   +3 more
doaj   +1 more source

Development of a Novel Synthetic Hydrogel Sealant for Effective Prevention of Liver Resection‐Associated Bile Leakage

Advanced Healthcare Materials, EarlyView.
A dual‐crosslinking poly(ethylene glycol) (PEG) hydrogel is presented that rapidly solidifies and progressively adheres to tissue, achieving durable sealing of bile leaks. In hepatectomy models, this system prevents postoperative complications more effectively than conventional sealants, highlighting its translational potential as a safe and efficient ...
Kazuyoshi Matsubara, Shohei Ishikawa, Hiroyuki Kamata, Almog Gur, Ayano Fujisawa, Shu Nishida, Katsuyuki Hoshina, Takamasa Sakai   +7 more
wiley   +1 more source

Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals

Scientific Reports
An aqueous solution of a common food dye, Fast Green FCF (FG), mimics cholyl-lysyl-fluorescein to visualize embryonic bile flow via single peritoneal injection into intrauterine mouse embryos.
Tomoyuki Niimi, Nanae Miyazaki, Hironobu Oiki, Mami Uemura, Shihan Zeng, Watcharapon Promsut, Noriaki Ota, Shunji Nonaka, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Shohei Takami, Jun Fujishiro, Yoshiakira Kanai   +16 more
doaj   +1 more source

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

Hepatology Communications, 2022
Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia, growth retardation, and fat‐soluble vitamin insufficiency.
Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A. J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y. L. Chiang, Frank J. Gonzalez, Yoon‐Kwang Lee   +15 more
doaj   +1 more source

Studies on bile pigments IV. Direct bilirubin in canine bile [PDF]

, 1956
Two forms of the direct bilirubin separated from the dried canine cholecystic bile were subjected to paper chromatography and emission or infra-red spectroscopy, and the following results were obtained: 1.
Sakamoto, Takeshi
core   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

An N-acyl glycyltaurine conjugate of deoxycholic acid in the biliary bile acids of the rabbit

Journal of Lipid Research, 1998
The biliary bile acid composition of the adult and neonatal domestic rabbit, as well as that of the adult brush rabbit, was characterized. In adult domestic rabbits, the dominant bile acid present was deoxycholic acid (88“% of total bile acids), a ...
Lee R. Hagey, Claudio D. Schteingart, Steven S. Rossi, H-T. Ton-Nu, Alan F. Hofmann   +4 more
doaj   +1 more source

Olfactory sensitivity to bile fluid and bile salts in the European eel (Anguilla anguilla), goldfish (Carassius auratus) and Mozambique tilapia (Oreochromis mossambicus) suggests a 'broad range' sensitivity not confined to those produced by conspecifics alone [PDF]

, 2013
Teleosts have high olfactory sensitivity to bile salts. To assess whether this phenomenon is involved in intra-specific chemical communication alone, or is part of a more ‘broad range’ sensitivity to bile salts produced by heterospecifics, we ...
Agulleiro, Almeida, Appelt, Barata, Barata, Chatman, Davey, Døving, Frade, Fuss, Goto, Hansen, Haslewood, Hofmann, Hofmann, Hubbard, Hubbard, Hubbard, Huertas, Huertas, Huertas, Jellyman, Kobayashi, Kristensen, Li, Marshall, Mathis, Miranda, Moschetta, Polkinghorne, Rosenthal, Rossi, Sasaki, Scott, Siefkes, Sorensen, Sorensen, Stacey, Suzuki, Takei, Tesch, van Ginneken, Velez, Vermeirssen, Wilson, Zar, Zhang, Zhang   +47 more
core   +2 more sources

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source