Results 51 to 60 of about 5,534,791 (400)

Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

Signal Transduction and Targeted Therapy
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro-inflammatory/anti-inflammatory balance.
Joshua S. Fleishman, Sunil Kumar
semanticscholar   +1 more source

Navigating cholestasis: identifying inborn errors of bile acid metabolism for precision diagnosis

Frontiers in Pediatrics
Inborn errors of bile acid metabolism (IEBAM) cause cholestasis during the neonatal period, and 8 types of IEBAM have been reported to date. IEBAM accounts for approximately 2% of cases of cholestasis of unknown cause.
Hiroshi Nittono, Mitsuyoshi Suzuki, Hiromi Suzuki, Hiromi Suzuki, Satoru Sugimoto, Jun Mori, Rieko Sakamoto, Yugo Takaki, Hisamitsu Hayashi, Hajime Takei, Akihiko Kimura   +10 more
doaj   +1 more source

Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury [PDF]

arXiv, 2023
During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the liver. Our recent study has shown a correlation between the bile-to-plasma ratio of FDA-approved sodium fluorescein (SF)
arxiv  

Peristaltic flow of a fluid in a porous channel: A study having relevance to flow of bile within ducts in a pathological state [PDF]

International Journal of Engineering Science (IJES), Volume: 49, Issue: 9(2011) pp. 950-966, 2011
The paper deals with a theoretical study of the transport of a fluid in a channel, which takes place by the phenomenon of peristalsis. A mathematical analysis of the said problem has been presented. The analysis involves the application of a suitable perturbation technique. The velocity profile and the critical pressure for the occurrence of reflux are
arxiv   +1 more source

Bile Acids in Porcine Fetal Bile.

Biological and Pharmaceutical Bulletin, 2000
A study of the biliary bile acid composition in porcine fetus compared with that of the adult pig is described. Biles, collected during gestation (weeks 4, 15 to 17 and at birth), aged six months and two years old, were analyzed by gas-liquid chromatography and capillary GC-MS. Bile acids were separated into different conjugate groups by chromatography
Takako Masui, Taiju Kuramoto, Masaki Konishi, Junko Miyamoto, Takahiko Hoshita, Mizuho Une   +5 more
openaire   +4 more sources

Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]

, 2018
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan, Dunn, Kenneth W., Dunn, Robert T., Morgan, Ryan E., Ryan, Jennifer, Volak, Laurie P.   +5 more
core   +1 more source

Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile.

PLoS Neglected Tropical Diseases, 2020
The liver fluke Clonorchis sinensis inhabits the bile ducts, where bile concentration disparities across the fluke cell membrane can cause bile intoxication. Sodium-bile acid co-transporter (SBAT) plays a crucial role in bile acid recycling.
Fuhong Dai, Won Gi Yoo, Yanyan Lu, Jin-Ho Song, Ji-Yun Lee, Youngro Byun, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong   +8 more
doaj   +1 more source

Low-dose ursodeoxycholic acid prolongs cholesterol nucleation time in gallbladder bile of patients with cholesterol gallstones [PDF]

, 1989
The high rate of stone recurrence represents a drawback of non-surgical therapy of cholesterol gallstone disease. Although most studies report that long-term bile acid treatment does not have protective effects, preliminary results suggest that low-dose ...
Brenner, Gerhard, Jüngst, Dieter, Paumgartner, Gustav, Pratschke, Ekkehard   +3 more
core   +1 more source

Dominant Bacterial Phyla from the Human Gut Show Widespread Ability To Transform and Conjugate Bile Acids

mSystems, 2021
Gut bacteria influence human physiology by chemically modifying host-synthesized primary bile acids. These modified bile acids, known as secondary bile acids, can act as signaling molecules that modulate host lipid, glucose, and energy metabolism and ...
L. N. Lucas, K. Barrett, R. L. Kerby, Q. Zhang, L. E. Cattaneo, D. Stevenson, F. E. Rey, D. Amador-Noguez   +7 more
doaj   +1 more source

Bile Acids Conjugation in Human Bile Is Not Random: New Insights from 1H-NMR Spectroscopy at 800 MHz [PDF]

, 2009
Bile acids constitute a group of structurally closely related molecules and represent the most abundant constituents of human bile. Investigations of bile acids have garnered increased interest owing to their recently discovered additional biological ...
Cooper, Amanda, Maluccio, Mary, Nagana Gowda, G. A., Raftery, Daniel, Shanaiah, Narasimhamurthy   +4 more
core   +1 more source