Results 31 to 40 of about 371,534 (304)

Deficiency of Capicua disrupts bile acid homeostasis [PDF]

, 2018
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Choi, N, Fryer, JD, Hwang, D, Jung, HY, Kang, H, Kim, E, KIM, KYONG TAI, Kim, S, Lee, J, LEE, YOONTAE, Park, S, Yoe, J, Zoghbi, HY   +12 more
core   +2 more sources

Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits

Journal of Lipid Research, 2000
We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu, Benjamin L. Shneider, Sarah Shefer, Lien B. Nguyen, Ashok K. Batta, G. Stephen Tint, Marco Arrese, Sundararajah Thevananther, Lin Ma, Siegfried Stengelin, Werner Kramer, David Greenblatt, Mark Pcolinsky, Gerald Salen   +13 more
doaj   +1 more source

Navigating cholestasis: identifying inborn errors of bile acid metabolism for precision diagnosis

Frontiers in Pediatrics
Inborn errors of bile acid metabolism (IEBAM) cause cholestasis during the neonatal period, and 8 types of IEBAM have been reported to date. IEBAM accounts for approximately 2% of cases of cholestasis of unknown cause.
Hiroshi Nittono, Mitsuyoshi Suzuki, Hiromi Suzuki, Hiromi Suzuki, Satoru Sugimoto, Jun Mori, Rieko Sakamoto, Yugo Takaki, Hisamitsu Hayashi, Hajime Takei, Akihiko Kimura   +10 more
doaj   +1 more source

Bile Acids Conjugation in Human Bile Is Not Random: New Insights from 1H-NMR Spectroscopy at 800 MHz [PDF]

, 2009
Bile acids constitute a group of structurally closely related molecules and represent the most abundant constituents of human bile. Investigations of bile acids have garnered increased interest owing to their recently discovered additional biological ...
Cooper, Amanda, Maluccio, Mary, Nagana Gowda, G. A., Raftery, Daniel, Shanaiah, Narasimhamurthy   +4 more
core   +1 more source

A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis. [PDF]

, 2019
Primary biliary cholangitis (PBC) is typically associated with elevated serum bile acid levels and pruritus, but pruritus is often refractory to treatment with existing therapies.
Apostol, George, Bacon, Bruce, Bowlus, Christopher L, Dorenbaum, Alejandro, Gu, Joan, Hirschfield, Gideon M, Jones, David, Kennedy, Ciara, Levy, Cynthia, Luketic, Velimir, Mayo, Marlyn J, Medendorp, Sharon, Novak, Patricia, Patanwala, Imran, Pockros, Paul J, Vuppalanchi, Raj   +15 more
core   +2 more sources

Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile.

PLoS Neglected Tropical Diseases, 2020
The liver fluke Clonorchis sinensis inhabits the bile ducts, where bile concentration disparities across the fluke cell membrane can cause bile intoxication. Sodium-bile acid co-transporter (SBAT) plays a crucial role in bile acid recycling.
Fuhong Dai, Won Gi Yoo, Yanyan Lu, Jin-Ho Song, Ji-Yun Lee, Youngro Byun, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong   +8 more
doaj   +1 more source

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man [PDF]

, 2011
Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously ...
Amelsberg A, Batzri S, Beuers U, Beuers U, Douglas M. Jefferson, Duane WC, Eastwood GL, Hofmann AF, Hohenester S, Hov JR, Lucas Maillette de Buy Wenniger, Medina JF, Melero S, Minagawa N, Poupon R, Prieto J, Prieto J, Ronald P. Oude Elferink, Rust C, Simon Hohenester, Spivey JR, Ulrich Beuers   +21 more
core   +1 more source

Cholestyramine treatment in two dogs with presumptive bile acid diarrhoea: a case report

Canine Medicine and Genetics, 2021
Background In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome.
L. Toresson, J. M. Steiner, J. S. Suchodolski   +2 more
doaj   +1 more source

Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium

Journal of Lipid Research, 2012
The human bile acid pool composition is composed of both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid).
Jason M. Ridlon, Phillip B. Hylemon
doaj   +1 more source

Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats [PDF]

, 2013
Background. Significant physiological changes occur during pregnancy and lactation. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease closely related to disruption of bile acid homeostasis.
Dan Zhang, Hong M. Xie, Jie Liu, Qiong N. Zhu, Yuan F. Lu   +4 more
core   +1 more source