Results 51 to 60 of about 2,848,630 (309)

Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease [PDF]

, 1993
There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients.
Niemeyer, A., Ritter, C., Lange, V., Pozo, R., Meyer, L., Jüngst, Dieter, Richter, Werner O., Brandl, H., Möhrle, W.   +8 more
core   +1 more source

Efficacy and safety of switching therapy from chenodeoxycholic acid to cholic acid in Japanese patients with bile acid synthesis disorders

Molecular Genetics and Metabolism Reports
Objectives: This study aimed to assess the safety and efficacy of cholic acid (CA) treatment over 74 weeks in Japanese patients with inherited enzymatic bile acid synthesis disorders (BASD).
Mitsuyoshi Suzuki, Hajime Takei, Hiromi Suzuki, Jun Mori, Satoru Sugimoto, Tatsuki Mizuochi, Akira Ohtake, Hisamitsu Hayashi, Akihiko Kimura, Hiroshi Nittono   +9 more
doaj   +1 more source

Biological function of bile acid and its application prospect in aquaculture

Siliao yanjiu, 2023
Bile acid is an important active component of bile, which mainly includes bile acid, deoxycholic acid, taurine chenodeoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid and other components.
XU Chang-feng, WANG Hai-li
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Association between cholesterol-phospholipid vesicles and cholesterol crystals in human gallbladder bile [PDF]

, 1989
Rapid aggregation of cholesterol-phospholipid vesicles in gallbladder bile seems to be the first event in the production of cholesterol crystals, a prerequisite for cholesterol gallstone formation.
Schriever, Carolin Erika, Jüngst, Dieter   +1 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Comparative genomics of lactic acid bacteria reveals a niche-specific gene set [PDF]

, 2009
peer-reviewedBackground: The recently sequenced genome of Lactobacillus helveticus DPC4571 1 revealed a dairy organism with significant homology (75% of genes are homologous) to a probiotic bacteria Lb. acidophilus NCFM 2. This led us to hypothesise that
O\u27Callaghan, John, Callanan, Michael J., Fitzgerald, Gerald F, Gerald F Fitzgerald, Sangrador-Vegas, Amaia, Kaleta Pawel, O'Callaghan John, O'Sullivan, Orla, Fitzgerald Gerald F, Callanan Michael, O\u27Sullivan, Orla, Ross, R. Paul, Fitzgerald, Gerald F., Michael Callanan, O'Callaghan, John, Tom Beresford, Orla O'Sullivan, O'Sullivan Orla, Beresford, Thomas P., John O'Callaghan, Ross R Paul, Kaleta, Pawel, McAuliffe Olivia, Beresford, Tom, Olivia McAuliffe, Lydia Slattery, Amaia Sangrador-Vegas, McAuliffe, Olivia, Slattery Lydia, Pawel Kaleta, R Paul Ross, Slattery, Lydia, Beresford Tom, Ross, R Paul, Callanan, Michael, Sangrador-Vegas Amaia, O'Sullivan, Orla, O'Callaghan, John   +37 more
core   +1 more source

Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals

Scientific Reports
An aqueous solution of a common food dye, Fast Green FCF (FG), mimics cholyl-lysyl-fluorescein to visualize embryonic bile flow via single peritoneal injection into intrauterine mouse embryos.
Tomoyuki Niimi, Nanae Miyazaki, Hironobu Oiki, Mami Uemura, Shihan Zeng, Watcharapon Promsut, Noriaki Ota, Shunji Nonaka, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Shohei Takami, Jun Fujishiro, Yoshiakira Kanai   +16 more
doaj   +1 more source

Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is unknown.
Anne S. Henkel, Brian LeCuyer, Shantel Olivares, Richard M. Green   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source