Results 21 to 30 of about 207,201 (166)

Navigating cholestasis: identifying inborn errors of bile acid metabolism for precision diagnosis

Frontiers in Pediatrics
Inborn errors of bile acid metabolism (IEBAM) cause cholestasis during the neonatal period, and 8 types of IEBAM have been reported to date. IEBAM accounts for approximately 2% of cases of cholestasis of unknown cause.
Hiroshi Nittono, Mitsuyoshi Suzuki, Hiromi Suzuki, Hiromi Suzuki, Satoru Sugimoto, Jun Mori, Rieko Sakamoto, Yugo Takaki, Hisamitsu Hayashi, Hajime Takei, Akihiko Kimura   +10 more
doaj   +1 more source

Bile acid transporters [PDF]

Journal of Lipid Research, 2009
In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation.
Paul A. Dawson, Tian Lan, Anuradha Rao
openaire   +3 more sources

Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile.

PLoS Neglected Tropical Diseases, 2020
The liver fluke Clonorchis sinensis inhabits the bile ducts, where bile concentration disparities across the fluke cell membrane can cause bile intoxication. Sodium-bile acid co-transporter (SBAT) plays a crucial role in bile acid recycling.
Fuhong Dai, Won Gi Yoo, Yanyan Lu, Jin-Ho Song, Ji-Yun Lee, Youngro Byun, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong   +8 more
doaj   +1 more source

Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment.

Journal of Lipid Research, 1989
We have studied the effect of ursodeoxycholic acid on the serum and urinary bile acids in seven patients with moderate to severe primary biliary cirrhosis.
A K Batta, R Arora, G Salen, G S Tint, D Eskreis, S Katz   +5 more
doaj   +1 more source

Cholestyramine treatment in two dogs with presumptive bile acid diarrhoea: a case report

Canine Medicine and Genetics, 2021
Background In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome.
L. Toresson, J. M. Steiner, J. S. Suchodolski   +2 more
doaj   +1 more source

Bile acid profiles in adult patients with biliary atresia who achieve native liver survival after portoenterostomy

Scientific Reports
Bile acids have received increasing attention as a marker of the long-term prognosis and a potential therapeutic target in patients with biliary atresia, which is a progressive disease of the hepatobiliary system. A detailed analysis of serum and urinary
Masahiro Takeda, Hajime Takei, Mitsuyoshi Suzuki, Takafumi Tsukui, Koichi Tsuboi, Hiroko Watayo, Takanori Ochi, Hiroyuki Koga, Hiroshi Nittono, Atsuyuki Yamataka   +9 more
doaj   +1 more source

Biological function of bile acid and its application prospect in aquaculture

Siliao yanjiu, 2023
Bile acid is an important active component of bile, which mainly includes bile acid, deoxycholic acid, taurine chenodeoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid and other components.
XU Chang-feng, WANG Hai-li
doaj  

Efficacy and safety of switching therapy from chenodeoxycholic acid to cholic acid in Japanese patients with bile acid synthesis disorders

Molecular Genetics and Metabolism Reports
Objectives: This study aimed to assess the safety and efficacy of cholic acid (CA) treatment over 74 weeks in Japanese patients with inherited enzymatic bile acid synthesis disorders (BASD).
Mitsuyoshi Suzuki, Hajime Takei, Hiromi Suzuki, Jun Mori, Satoru Sugimoto, Tatsuki Mizuochi, Akira Ohtake, Hisamitsu Hayashi, Akihiko Kimura, Hiroshi Nittono   +9 more
doaj   +1 more source

Examination of bile acid negative feedback regulation in rats.

Journal of Lipid Research, 1988
Recent data obtained using cultured rat hepatocytes showed that bile acids do not inhibit bile acid synthesis, whereas cholesterol concentrations vary in parallel with bile acid synthesis (Davis et al. (1983. J. Biol. Chem. 258: 4079-4082).
R A Davis, C A Musso, M Malone-McNeal, G R Lattier, P M Hyde, J Archambault-Schexnayder, M Straka   +6 more
doaj   +1 more source

Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals

Scientific Reports
An aqueous solution of a common food dye, Fast Green FCF (FG), mimics cholyl-lysyl-fluorescein to visualize embryonic bile flow via single peritoneal injection into intrauterine mouse embryos.
Tomoyuki Niimi, Nanae Miyazaki, Hironobu Oiki, Mami Uemura, Shihan Zeng, Watcharapon Promsut, Noriaki Ota, Shunji Nonaka, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Shohei Takami, Jun Fujishiro, Yoshiakira Kanai   +16 more
doaj   +1 more source