Application of a novel tool for diagnosing bile acid diarrhoea [PDF]
, 2013 Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs.
Arasaradnam, Ramesh P. +27 more
core +1 more source
Journal of Lipid Research, 1984 Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
doaj +1 more source
Role of High total protein in gallbladder bile in the formation of cholesterol gallstones. [PDF]
, 1991 While it is generally accepted that cholesterol supersaturation of bile is of key importance in the rapid formation of cholesterol crystals, the role of total biliary protein and pH in the pathogenesis of cholesterol gallstones is less well understood ...
Ritter, Christoph von +3 more
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Bile Acids in Porcine Fetal Bile.
Biological and Pharmaceutical Bulletin, 2000 A study of the biliary bile acid composition in porcine fetus compared with that of the adult pig is described. Biles, collected during gestation (weeks 4, 15 to 17 and at birth), aged six months and two years old, were analyzed by gas-liquid chromatography and capillary GC-MS. Bile acids were separated into different conjugate groups by chromatography
KURAMOTO, Taiju +5 more
openaire +3 more sources
Hepatic bile acid uptake: effect of conjugation, hydroxyl and keto groups, and albumin binding
Journal of Lipid Research, 1982 Hepatic extraction of trihydroxy (free, glyco- and tauro-conjugated) dihydroxy, and monohydroxy bile acids has been evaluated in single pass liver perfusion experiments in rats.
R Aldini +5 more
doaj +1 more source
The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]
, 2013 Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
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Effect of phospholipids and bile acids on cholesterol nucleation time and vesicular/micellar cholesterol in gallbladder bile of patients with cholesterol stones [PDF]
, 1993 Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their ...
Paumgartner, Gustav +4 more
core +1 more source
Diversification of host bile acids by members of the gut microbiota
Gut Microbes, 2020 Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host hepatocytes synthesize primary bile acids from cholesterol.
Jenessa A. Winston, Casey M. Theriot
doaj +1 more source
Mutations in SRD5B1 (AKR1D1), the gene encoding Delta(4)-3-oxosteroid 5 beta-reductase, in hepatitis and liver failure in infancy [PDF]
, 2003 Background: A substantial group of patients with cholestatic liver disease in infancy excrete, as the major urinary bile acids, the glycine and taurine conjugates of 7alpha-hydroxy-3-oxo-4-cholenoic acid and 7alpha, 12alpha-dihydroxy-3- oxo-4-cholenoic ...
Duran, M. +17 more
core +2 more sources
Recent advances in understanding bile acid homeostasis [version 1; referees: 2 approved]
F1000Research, 2017 Bile acids are derived from cholesterol to facilitate intestinal nutrient absorption and biliary secretion of cholesterol. Recent studies have identified bile acids as signaling molecules that activate nuclear farnesoid X receptor (FXR) and membrane G ...
John YL Chiang
doaj +1 more source