Results 61 to 70 of about 354,033 (333)
Advanced Robotics Research, EarlyView.Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen +3 more
wiley +1 more source
Paclitaxel chemotherapy disrupts microbiota-enterohepatic bile acid metabolism in mice
Gut MicrobesBalanced interactions between the enteric microbiota and enterohepatic organs are essential to bile acid homeostasis, and thus normal gastrointestinal function.
Brett R. Loman +8 more
doaj +1 more source
Bile acids drive chemotaxis of Clonorchis sinensis juveniles to the bile duct. [PDF]
PLoS Neglected Tropical Diseases, 2018 Clonorchiasis is a neglected tropical disease caused by Chinese liver fluke, Clonorchis sinensis infection. C. sinensis is a biological carcinogen causing cholangiocarcinoma in humans. In the mammalian host, C.
Shunyu Li +4 more
doaj +1 more source
Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance. [PDF]
, 2012 Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype ...
Bäumler, Andreas J +6 more
core
Deficiency of Capicua disrupts bile acid homeostasis [PDF]
, 2018 Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Choi, N +12 more
core +2 more sources
Advanced Science, EarlyView.This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu +13 more
wiley +1 more source
Protection of dried probiotic bacteria from bile using bile adsorbent resins [PDF]
, 2014 Enteric coated oral tablets or capsules can deliver dried live cells directly into the intestine. Previously, we found that a live attenuated bacterial vaccine acquired sensitivity to intestinal bile when dried, raising the possibility that although ...
Alexander D. Edwards +19 more
core +1 more source
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice [PDF]
, 2016 Ethnopharmacological relevanceGentiopicroside (GPS), one of iridoid glucoside representatives, is the most potential active component in Gentiana rigescens Franch. ex Hemsl and Gentiana macrophylla Pall.
Gong, Junting +6 more
core +1 more source
Advanced Science, EarlyView.The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou +11 more
wiley +1 more source