Results 71 to 80 of about 39,146 (248)

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Variation in bile acid synthesis capacity: A key factor leading to different lipid deposition patterns in goldfish breeds

Aquaculture Reports
In our previous study, we observed distinct lipid deposition pattern between Crane-top red goldfish (HDH) and Pearl-scale goldfish (PS), yet the regulatory mechanisms remained unclear.
Jianqiao Wang, Fangxi Li, Wenhao Qin, Yuanyuan Fu, Xiaojing Dong, Tao Wang, Xuedi Du   +6 more
doaj   +1 more source

Evidence for a lack of regulatory importance of the 12 alpha-hydroxylase in formation of bile acids in man: an in vivo study.

Journal of Lipid Research, 1983
The possibility that the 12 alpha-hydroxylase involved in formation of bile acids is of regulatory importance for the ratio between cholic acid and chenodeoxycholic acid in bile was studied with an in vivo technique.
I Björkhem, M Eriksson, K Einarsson
doaj   +1 more source

Investigation of dichlorodiphenyltrichloroethane (DDT) on xenobiotic enzyme disruption and metabolomic bile acid biosynthesis in DDT-sprayed areas using wild rats. [PDF]

J Vet Med Sci, 2023
Motohira K, Yohannes YB, Ikenaka Y, Eguchi A, Nakayama SM, Wepener V, Smit NJ, VAN Vuren JH, Ishizuka M.   +8 more
europepmc   +1 more source

Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle

BMC Genomics, 2011
Background Divergently selected Lean and Fat mouse lines represent unique models for a polygenic form of resistance and susceptibility to obesity development. Previous research on these lines focused mainly on obesity-susceptible factors in the Fat line.
Fievet Catherine, Fazarinc Gregor, Rozman Damjana, Juvan Peter, Režen Tadeja, Simončič Matjaž, Staels Bart, Horvat Simon   +7 more
doaj   +1 more source

Supplementation of Weizmannia coagulans BC2000 and Ellagic Acid Inhibits High-Fat-Induced Hypercholesterolemia by Promoting Liver Primary Bile Acid Biosynthesis and Intestinal Cholesterol Excretion in Mice. [PDF]

Microorganisms, 2023
Jin L, Dang H, Wu J, Yuan L, Chen X, Yao J.   +5 more
europepmc   +1 more source

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis[S]

Journal of Lipid Research, 2012
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates fatty acid transport and metabolism. Previous studies revealed that PPARα can affect bile acid metabolism; however, the mechanism by which PPARα regulates bile acid
Fei Li, Andrew D. Patterson, Kristopher W. Krausz, Naoki Tanaka, Frank J. Gonzalez   +4 more
doaj   +1 more source

Corrigendum: Identification of Mitochondrial-Related Prognostic Biomarkers Associated With Primary Bile Acid Biosynthesis and Tumor Microenvironment of Hepatocellular Carcinoma. [PDF]

Front Oncol, 2021
Zhang T, Nie Y, Gu J, Cai K, Chen X, Li H, Wang J.   +6 more
europepmc   +1 more source

Expression of cholesterol 7α-hydroxylase and Δ4-3-ketosteroid 5β-reductase genes in rat pancreatic hepatocyte-like cells

Journal of Lipid Research, 1999
Hepatocyte-like cells have been observed in the pancreas of the rat. We examined the bile acid biosynthetic function of these cells to determine whether they were real hepatocytes.
Yoshihisa Ando, Hideyuki Ide, Shuji Kosai, Ryo Kamimura, Yorio Maeda, Shushi Higashi, Toshiaki Setoguchi   +6 more
doaj   +1 more source