Results 81 to 90 of about 2,795,829 (201)

The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor actovator that can act as a suppressor of bile acid biosynthesis [PDF]

, 2004
Two key regulatory enzymes in the bile acid biosynthesis pathway are cholesterol 7alpha-hydroxylase/CYP7A1 (7alpha-hydroxylase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase).
Del Castillo-Olivares, Antonio, Gil, Gregorio, Pandak, William M., Campos-Sandoval, José Ángel   +3 more
core   +1 more source

Recapitulation of bile acid metabolism in hepatobiliary organoids derived from hiPSC

JHEP Reports
Background & Aims: Bile acids are crucial mediators of cholesterol homeostasis, lipid digestion, and detoxification, and reliable in vitro synthesis systems are essential for liver disease research and precision medicine.
Junming Xu, Xiaopu Sang, Jie Ke, Jingyi Li, Jiasen Xu, Xiaoni Chen, Shan Lin, Ruijie Cai, Xianjie Shi, Fenfang Wu   +9 more
doaj   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers [PDF]

, 2003
Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA).
Zöllner, N., Adam, Olaf, Wolfram, G.
core   +1 more source

Cross-Omics Analyses Reveal the Effects of Ambient PM_2.5 Exposure on Hepatic Metabolism in Female Mice

Toxics
Ambient particulate matter (PM2.5) is a potential risk factor for metabolic damage to the liver. Epidemiological studies suggest that elevated PM2.5 concentrations cause changes in hepatic metabolism, but there is a lack of laboratory evidence.
Ruifeng Yan, Shaoyang Ji, Tingting Ku, Nan Sang   +3 more
doaj   +1 more source

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Fibronectin in human gallbladder bile: cholesterol pronucleating and/or mucin "link" protein? [PDF]

, 1994
Some biliary proteins (pronucleators) seem to be essential factors for cholesterol crystal formation and crystal growth in bile. A recent study suggests that fibronectin is such a pronucleator in bile.
Ritter, Christoph von, Lange, Volker, Del Pozo, Reginals, Paumgartner, Gustav, V. Lange, J. F. Miquel, R. Del Pozo, G. Paumgartner, Jüngst, Dieter, Miquel, Juan Francisco, C. Von Ritter, D. Jungst   +11 more
core   +1 more source

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor

Journal of Lipid Research, 2004
Bile acid synthesis from cholesterol is tightly regulated via a feedback mechanism mediated by the farnesoid X receptor (FXR), a nuclear receptor activated by bile acids.
Tomoko Nishimaki-Mogami, Mizuho Une, Tomofumi Fujino, Yoji Sato, Norimasa Tamehiro, Yosuke Kawahara, Koichi Shudo, Kazuhide Inoue   +7 more
doaj   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Bile Acid Biosynthesis Avoiding Cholesterol

, 2018
Bile acids are the end products of cholesterol metabolism secreted into bile. They are essential for the absorption of lipids and lipid soluble compounds from the intestine.
Iida, T, Abdel-Khalik, J, Crick, PJ, Morris, AA, Shackleton, CH, Clayton, PT, Yutuc, E, Ogundare, M, Griffiths, WJ, Bigger, BW   +9 more
core   +1 more source