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Bile acid signaling: from dynamic pool composition to inter-organ communication. [PDF]
Front Endocrinol (Lausanne)Yang F, Wei T, Liu K, Chu H, Yang L.
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Bile acid transport in cultured rat hepatocytes
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1982 The mechanisms of bile acid uptake have been studied with primary monolayer cultures of rat hepatocytes. Hepatocytes were incubated with taurocholic acid (TC), glycocholic acid (GC), cholic acid (CA), glycochenodeoxycholic acid (GCDC), chenodeoxycholic acid (CDCA), deoxycholic acid (DOCA), lithocholic acid (LCA), or cholylglycylhistamine (CCH), a ...
R W, Van Dyke +2 more
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Bile acid transport systems as pharmaceutical targets
European Journal of Clinical Investigation, 1996W, Kramer, G, Wess
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Gastroenterology Clinics of North America, 1999
Bile acids undergo a unique enterohepatic circulation, which allows them to be efficiently reused with minimal loss. With the cloning of key bile acid transporter genes in the liver and intestine, clinicians now have a detailed understanding of how the different components in the enterohepatic circulation operate.
R J, Bahar, A, Stolz
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Bile acids undergo a unique enterohepatic circulation, which allows them to be efficiently reused with minimal loss. With the cloning of key bile acid transporter genes in the liver and intestine, clinicians now have a detailed understanding of how the different components in the enterohepatic circulation operate.
R J, Bahar, A, Stolz
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Current Opinion in Lipidology, 1995
The sodium-dependent bile acid transporters and sodium-independent organic anion transporters are integral membrane glycoproteins that function in the enterohepatic circulation of bile acids. The recent cloning and expression of different classes of bile acid transporters have provided insights into their structure and molecular mechanism.
P A, Dawson, P, Oelkers
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The sodium-dependent bile acid transporters and sodium-independent organic anion transporters are integral membrane glycoproteins that function in the enterohepatic circulation of bile acids. The recent cloning and expression of different classes of bile acid transporters have provided insights into their structure and molecular mechanism.
P A, Dawson, P, Oelkers
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Intracellular transport of bile acids
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000Bile acids originate from the liver and are transported via bile to the intestines where they perform an important role in the absorption of lipids and lipid-soluble nutrients. Most of the bile acids are reclaimed from the terminal ileum and returned to the liver via portal blood for reuse.
L B, Agellon, E C, Torchia
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Bile acid and xenobiotic transporters in liver
Current Opinion in Cell Biology, 1998Identification of transporters involved in bile formation in liver is rapidly progressing. It is now clear that these transporters are also important in drug disposition in the body. Significant recent advances include the cloning of an ATP-dependent bile acid transporter, related to the p-glycoprotein family, in the canalicular plasma membrane of ...
Stieger, B., Meier, P. J.
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New insights into bile acid transport
Current Opinion in Lipidology, 1998The enterohepatic circulation of bile acids is maintained by a series of membrane transport proteins. Recent studies of the cloned sodium bile acid cotransporters have provided new insights into their tissue expression, regulation, and their relationship to cholesterol homeostasis and human diseases such as primary bile acid malabsorption.
M W, Love, P A, Dawson
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Transport and biological activities of bile acids
The International Journal of Biochemistry & Cell Biology, 2013Bile acids have emerged as important biological molecules that support the solubilization of various lipids and lipid-soluble compounds in the gut, and the regulation of gene expression and cellular function. Bile acids are synthesized from cholesterol in the liver and eventually released into the small intestine.
Brittnee L, Zwicker, Luis B, Agellon
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Intestinal transport of bile acids
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1981The intestinal absorption of bile acids is determined by two resistances: diffusion through an unstirred water layer and penetration of the cell membrane. Passive jejunal uptake of polar bile acids is limited by the mucosal membrane, whereas the unstirred layer exerts resistance on uptake of more nonpolar species.
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