Results 261 to 270 of about 4,715,473 (300)

Bile acid transport in the anhepatic rat

Gastroenterology, 1992
Hepatocyte dysfunction eventually results in the loss of canalicular bile formation. Without canalicular flow, intestinal bile acid may originate from plasma by reverse transport. Anhepatic rats with preserved intestinal function permit evaluation of such transport. In the present study, plasma taurocholate clearance was markedly decreased in anhepatic
G, Cucchiaro, W C, Meyers, S L, Young, G D, Branum, S, Quarfordt   +4 more
openaire   +2 more sources

Hepatobiliary transport of bile acid amino acid, bile acid peptide, and bile acid oligonucleotide conjugates in rats

Hepatology, 1999
Uptake of drugs by bile acid carriers could account for the selectivity of drug actions in the gut and liver. We have previously shown that conjugation of xenobiotics with bile acids facilitates their transfer to hepatocytes and ileal enterocytes.
E, Petzinger, A, Wickboldt, P, Pagels, D, Starke, W, Kramer   +4 more
openaire   +2 more sources

The solute carrier family 10 (SLC10): Beyond bile acid transport

Molecular Aspects of Medicine, 2013
The solute carrier (SLC) family 10 (SLC10) comprises influx transporters of bile acids, steroidal hormones, various drugs, and several other substrates.
James Polli, Peter Swaan, Tatiana Claro da Silva   +2 more
exaly   +2 more sources

Transporters for Bile Acids and Organic Anions

2002
The liver is one of the most important organs in the detoxification of xenobiotics. Compounds in the circulating blood are taken up by hepatocytes and then are metabolized and/or excreted into the bile. Many kinds of drugs and their metabolites are transported across the sinusoidal and bile canalicular membranes via carriermediated mechanisms.
H, Suzuki, Y, Sugiyama
openaire   +2 more sources

Bile acid transporter mediated endocytosis of oral bile acid conjugated nanocomplex

Biomaterials, 2017
The development of highly funtional and orally available nanoparticles is the ultimate goal in nanoparticle delivery. Various functional nanoparticles have been studied to that end but there has yet to be an oral nanoparticle that can be successfully applied.
Jooho, Park, Jeong Uk, Choi, Kwangmeyung, Kim, Youngro, Byun   +3 more
openaire   +2 more sources

TOLUENE-INDUCED ELEVATION OF SERUM BILE ACIDS: RELATIONSHIP TO BILE ACID TRANSPORT

Journal of Toxicology and Environmental Health, 1997
Raised concentrations of serum bile acids (SBA) following occupational exposure to a number of halogenated aliphatic hydrocarbon solvents and after in vivo exposure of experimental animals to these substances have been reported in several studies in recent years.
M, Neghab, N H, Stacey
openaire   +2 more sources

A new bile acid transporter?

Hepatology, 1993
Transport systems involved in uptake and biliary secretion of bile salts have been extensively studied in rat liver; however, little is known about these systems in the human liver. In this study, we investigated taurocholate (TC) transport in canalicular and basolateral plasma membrane vesicles isolated from 15 human livers ...
W, Hardikar, F J, Suchy
openaire   +2 more sources

SLC10A4 is a protease-activated transporter that transports bile acids

Journal of Biochemistry, 2013
SLC10A4 belongs to the sodium bile acid cotransporter family, but has no transport activity for bile acids. We performed multiple amino acid alignments and examined the relationships between the SLC10 proteins. The extracellular N-terminus of SLC10A4 was predicted to be relatively longer at the amino acid level than those of SLC10A1, SLC10A2 and ...
Takuya, Abe, Yoshitomi, Kanemitu, Masateru, Nakasone, Ichiro, Kawahata, Tohru, Yamakuni, Akira, Nakajima, Naoto, Suzuki, Masazumi, Nishikawa, Takanori, Hishinuma, Yoshihisa, Tomioka   +9 more
openaire   +2 more sources

Hepatocellular bile acid transport and ursodeoxycholic acid hypercholeresis

Digestive Diseases and Sciences, 1989
This review focuses on mechanisms of bile acid transport across the basolateral and canalicular hepatocyte plasma membranes and on ursodeoxycholic acid (UDCA) hypercholeresis and biotransformation. Conjugated trihydroxy bile acids enter hepatocytes via a sodium-coupled mechanism localized to the basolateral membrane, which is saturable, concentrative ...
B F, Scharschmidt, J R, Lake
openaire   +2 more sources

Role of bile acid conjugation in hepatic transport of dihydroxy bile acids.

The Journal of Pharmacology and Experimental Therapeutics, 1989
The effect of conjugation and side chain length on dihydroxy bile acid unidirectional hepatic uptake and efflux was studied using the isolated perfused rat liver which was perfused prograde or retrograde in single pass fashion. Deoxycholic acid (DC) and its C23 (nor) derivative nor-DC, as well as the synthetically prepared taurine conjugate of DC, were
L M, Clayton, D, Gurantz, A F, Hofmann, L R, Hagey, C D, Schteingart   +4 more
openaire   +2 more sources