Results 271 to 280 of about 4,715,473 (300)

Hepatic Transport of Bile Acids

1976
The liver is responsible for the secretion of bile acids into bile and for the uptake and reexcretion of bile acids that participate in the enterohepatic circulation. In addition, the secretion of bile acids by the liver is of major importance for the secretion of bile itself and for the secretion of biliary lipids.
S. Erlinger, J. C. Glasinović, R. Poupon, M. Dumont   +3 more
openaire   +1 more source

Interaction of sulfonylureas with the transport of bile acids into hepatocytes

European Journal of Pharmacology, 1992
The sulfonylurea compounds glisoxepide and glibenclamide inhibit the uptake of bile acids into isolated rat hepatocytes. The Ki values for the inhibition of cholate uptake was 9 microM with glibenclamide and 200 microM with glisoxepide. The inhibition of cholate uptake by both sulfonylureas was noncompetitive.
D, Fückel, E, Petzinger
openaire   +2 more sources

Differential Interaction of Bile Acids from Patients with Inborn Errors of Bile Acid Synthesis with Hepatocellular Bile Acid Transporters

European Journal of Biochemistry, 1997
People with genetic or acquired defects in the biosynthesis of bile acids may suffer from cholestasis. Patients with a deficiency of 3β‐hydroxy‐Δ5‐C27‐steroid dehydrogenase/isomerase form 3β,7α‐dihydroxy‐and 3β,7α,12α‐trihydroxy‐5‐cholenoic acids, the sulfated and partially glycine‐conjugated forms of which are found in their urine and bile.
Stieger, B., Zhang, J., O'Neill, B., Sjövall, J., Meier, P. J.   +4 more
openaire   +2 more sources

Influence of side-chain charge on hepatic transport of bile acids and bile acid analogues

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1985
The importance of side-chain charge on hepatic uptake and biliary secretion of bile acids and analogues was studied using the isolated, perfused rat liver and the anesthetized rat with a bile fistula. Derivatives of cholic acid with negative, neutral, zwitterionic, or positive charges on the side chain were synthesized and studied.
M S, Anwer, E R, O'Maille, A F, Hofmann, R A, DiPietro, E, Michelotti   +4 more
openaire   +2 more sources

Modern Approaches to Bile Acid Transport Proteins

Hospital Practice, 1990
New techniques for studying solute uptake across epithelial membranes in the gut are providing a clearer picture of bile acid handling. In the small intestine, liver, and other sites, membrane proteins that mediate active bile acid transport are key players.
openaire   +2 more sources

Hepatobiliary Transport of Bile Acids

2017
Bile acids are the major driving force of bile excretion from hepatocytes; they are synthesized from cholesterol via at least 17 enzymatic reactions. They play a critical role in cholesterol disposal and the absorption of fat and fat-soluble vitamins.
openaire   +1 more source

The transport of bile acids in liver cells

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1988
M, Frimmer, K, Ziegler
openaire   +2 more sources

Deoxynivalenol increases pro-inflammatory cytokine secretion and reduces primary bile acid transport in an inflamed intestinal in vitro co-culture model

Food Research International, 2023
Hans Bouwmeester, Wouter Bakker, Laura de Haan   +2 more
exaly  

Hepatocellular Transport of Bile Acids

Seminars in Liver Disease, 1993
openaire   +2 more sources

Mice Deleted for Fatty Acid Transport Protein 5 Have Defective Bile Acid Conjugation and Are Protected From Obesity

Gastroenterology, 2006
Ruth E Gimeno
exaly