Results 251 to 260 of about 238,773 (337)

Effects of Several Bile Acids on the Production of Virulence Factors by Pseudomonas aeruginosa. [PDF]

Life (Basel)
Lomri N, Hulen C.
europepmc   +1 more source

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Vivian Rodriguez Cruz, Kenneth Cassidy   +6 more
wiley   +1 more source

Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury. [PDF]

EMBO Mol Med
Attema B, Kuipers F.
europepmc   +1 more source

Studies on Bile Salts of Toad (Bufo vulgaris japonicus). XI. Formation of Norcholic Acid from Δ²³-3(α), 7(α), 12(α)-Trihydroxycoprostenic Acid C₂₇H₄₄O₅ and Stem Acid C₂₇H₄₆O₂

, 1953
Shõhei Hayakawa
openalex   +2 more sources

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr, Shen Cheng, Mahmoud Al‐Kofahi, Christopher Staley, Pamala A. Jacobson   +4 more
wiley   +1 more source

Pharmacological Mechanisms of Bile Acids Targeting the Farnesoid X Receptor. [PDF]

Int J Mol Sci
Qi Y, Ma Y, Duan G.
europepmc   +1 more source

The Synthesis of Stero-bile Acid. VI. The Synthesis of Trihydroxycoprostane

, 1954
Taro Kazuno, A. Mori
openalex   +2 more sources

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Effects of supplementing bile acids on the production performance, fatty acid and bile acid composition, and gut microbiota in transition dairy cows. [PDF]

J Anim Sci Biotechnol
Li L, Li J, Liu Z, Jin Z, Wang M, Wu Y, Zhang Z, Hou X, Yao J, Zhang J.   +9 more
europepmc   +1 more source

Infant Death due to Cannabis Ingestion

Drug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Oriana Cuman, Anna Pagliaro, Fabio Mattiazzi, Cristina Basso, Maddalena Galeazzi   +9 more
wiley   +1 more source