Results 41 to 50 of about 138,323 (307)

Profiling of Urinary Glucuronidated Bile Acids across Age Groups

Metabolites, 2022
We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1 ...
Yamato Muto, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Hajime Takei, Hiroshi Nittono   +6 more
doaj   +1 more source

A Link between cholesterol levels and phenobarbital induction of cytochromes P450 [PDF]

, 2002
Squalestatin1 (SQ1), a potent inhibitor of squalene synthase produced a dose-dependent induction of cytochromes P450 CYP2H1 and CYP3A37 mRNAs in chicken hepatoma cells. The effect of SQ1 was completely reversed by 25-hydroxycholesterol.
Christoph Handschin, Handschin, C., Meyer, U. A., Urs A. Meyer, Kaufmann, M., Jean-Claude Ourlin, Michel Kaufmann, Ourlin, J. -C.   +7 more
core   +1 more source

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Beuers, Ulrich, Lehmann, Frank, Terracciano, Luigi, Hruz, Petr, Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen, Beglinger, Christoph   +7 more
core   +1 more source

A proposed nomenclature for bile acids.

Journal of Lipid Research, 1992
A proposal is made for a system of nomenclature of the more common unconjugated and conjugated bile acids. Acceptable trivial names for bile acids are tabulated, and guidelines are proposed for using these existing trivial names as roots to create ...
AF Hofmann, J Sjövall, G Kurz, A Radominska, CD Schteingart, GS Tint, ZR Vlahcevic, KD Setchell   +7 more
doaj   +1 more source

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

Metabolites, 2020
Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated with
Cristina Gómez, Simon Stücheli, Denise V. Kratschmar, Jamal Bouitbir, Alex Odermatt   +4 more
doaj   +1 more source

Bile acid transporters [PDF]

Journal of Lipid Research, 2009
In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation.
Paul A. Dawson, Tian Lan, Anuradha Rao
openaire   +3 more sources

Cholestasis: The Close Relationship between Bile Acids and Coenzyme Q10 [PDF]

, 2019
Cholestasis is defined as the impairment in formation or excretion of bile from the liver to the intestine. It may result from defects in intrahepatic production of bile, impairment of hepatic transmembrane transporters, or mechanical obstruction to bile
Martinefski, Manuela Romina, Valeria P. Tripodi, Lucangioli, Silvia Edith, Bianciotti, Liliana Graciela, Liliana G. Bianciotti, Silvia E. Lucangioli, Tripodi, Valeria Paula, Manuela R. Martinefski   +7 more
core   +1 more source

Novel microbially transformed bile acids: Biosynthesis, structure, and function

Pharmacological Research
The roles of gut microbiota and microbially modified bile acids in human health have become widely recognized. In the last five years, various microbially modified bile acids (e.g., proteinogenic amino-conjugated bile acids, polyamine-conjugated bile ...
Qi Zhao, Zilei Duan, Ren Lai, Pengcheng Ma   +3 more
doaj   +1 more source

Bile acids during pregnancy: Trimester variations and associations with glucose homeostasis

Health Science Reports, 2021
Background and aims Bile acids are known to contribute to hepatic glucose and lipid metabolism regulation. Although glucose homeostasis sustains well‐characterized modifications during uncomplicated pregnancies, changes in bile acids concentrations and ...
Marianne Gagnon, Jocelyn Trottier, S. John Weisnagel, Claudia Gagnon, Anne‐Marie Carreau, Olivier Barbier, Anne‐Sophie Morisset   +6 more
doaj   +1 more source

Regulation of bile acid synthesis in the rat: relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids.

Journal of Lipid Research, 1995
Bile acid biosynthesis has been believed to be regulated by negative feedback control; however, recent experiments have cast considerable doubts on the concept. The aim of the study was to examine the consensus of the negative feedback regulation of bile
K Fukushima, H Ichimiya, H Higashijima, H Yamashita, S Kuroki, K Chijiiwa, M Tanaka   +6 more
doaj   +1 more source