Results 71 to 80 of about 139,449 (267)
Advanced Science, EarlyView.A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu +6 more
wiley +1 more source
mBioBile acids play a critical role in the emulsification of dietary lipids, a critical step in the primary function of the small intestine, which is the digestion and absorption of food.
Jenni Firrman +7 more
doaj +1 more source
Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids
Acta Pharmaceutica Sinica B, 2015 The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy ...
Courtney B. Ferrebee, Paul A. Dawson
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Advanced Science, EarlyView.This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang +13 more
wiley +1 more source
An N-acyl glycyltaurine conjugate of deoxycholic acid in the biliary bile acids of the rabbit
Journal of Lipid Research, 1998 The biliary bile acid composition of the adult and neonatal domestic rabbit, as well as that of the adult brush rabbit, was characterized. In adult domestic rabbits, the dominant bile acid present was deoxycholic acid (88“% of total bile acids), a ...
Lee R. Hagey +4 more
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Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase [PDF]
, 1989 P. Hans, Piet Meijer, B.H.J. Hofstee
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Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription
Advanced Science, EarlyView.This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen +14 more
wiley +1 more source
Alteration of serum bile acids in non-small cell lung cancer identified by a validated LC–MS/MS method [PDF]
, 2023 Tongxin Yin +7 more
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Advanced Science, EarlyView.It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li +9 more
wiley +1 more source
Quantitative isolation and gas–liquid chromatographic analysis of total fecal bile acids
Journal of Lipid Research, 1965 A method for isolation and quantification of fecal bile acids is described which allows sterol balance studies to be made in man or in small laboratory animals without requiring the use of radioisotopes in vivo. Bile acids are purified by column and thin-
Scott M. Grundy +2 more
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