Results 91 to 100 of about 29,638 (318)

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Regulation of Cholesterol Catabolism by Bile Salts and Glycyrrhetic Acid in vivo.

Experimental Biology and Medicine, 1965
SummaryTritiated cholesterol was injected intraperitoneally into rats having 2 bile-duct cannulae, one for bile collection and the other for intraduodenal infusion of bile-salt solutions. Intraduodenal infusion of taurocholate (10 mg/hr) had no effect on rates of radioactive bile-salt formation from cholesterol-H3.
D. V. Parke, M. J. Lee, M. W. Whitehouse
openaire   +3 more sources

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Bile salts of the coelacanth, Latimeria chalumnae.

Journal of Lipid Research, 1984
Bile salts of the coelacanth, Latimeria chalumnae, Smith, have been analyzed and shown to have three bile alcohols, latimerol, 5 alpha-cyprinol, and 5 alpha-cholestane-3 beta, 7 alpha,-12 alpha,25,26-pentol, two C24 bile acids, chenodeoxycholic acid and ...
K Kihira, Y Akashi, S Kuroki, J Yanagisawa, F Nakayama, T Hoshita   +5 more
doaj  

UPLC‐ESI‐QTOF‐MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Plant extracts are emerging as valuable options for food additives and therapeutic treatments. This study evaluated the phytochemical profile, antioxidant activity, and cytotoxicity of aerial parts of Marrubium vulgare L. crude extract (MVCE) and its subfractions.
Ines El Mannoubi, Nuha M. Alghamdi, Seham H. Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N. Abdalla, Majdi Abid, Adel Kadri, Mozaniel Santana de Oliveira   +8 more
wiley   +1 more source

Studies on the Occurrence of Cholesterol in Water-Containing Liquid-Crystalline Form. II. The Formation of Cholesterol-Containing Mesomorphous Phases in the Presence of Protein-Association Colloid Complexes, Serum Albumin and Bile Acid Salts. [PDF]

, 1961
Per Ekwall, Herrick Baltscheffsky, Kristian Valen   +2 more
openalex   +1 more source

Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes

ChemElectroChem, EarlyView.
This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský, Natália Košútová, Lenka Lorencová, Peter Kasák, Tomáš Bertók, Ján Tkáč   +5 more
wiley   +1 more source

Evolution of the bile salt nuclear receptor FXR in vertebrates*s⃞

Journal of Lipid Research, 2008
Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive evolutionary changes.
Erica J. Reschly, Ni Ai, Sean Ekins, William J. Welsh, Lee R. Hagey, Alan F. Hofmann, Matthew D. Krasowski   +6 more
doaj  

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Increased cell loss in the human jejunum induced by laxatives (ricinoleic acid, dioctyl sodium sulphosuccinate, magnesium sulphate, bile salts). [PDF]

, 1981
J. Bretagne, N Vidon, C L'Hirondel, J J Bernier   +3 more
openalex   +1 more source