Results 121 to 130 of about 57,138 (354)

Mapping molluscan endocrinology: a systematic and critical appraisal

open access: yesBiological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis   +3 more
wiley   +1 more source

27-Hydroxycholesterol: production rates in normal human subjects

open access: yesJournal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +1 more source

Intestinal Absorption [PDF]

open access: yes, 2000
This is the edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine,in London, on 9 February 1999. First published by the Wellcome Trust, 2000.
Christie, DA, Tansey, EM
core  

Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine [PDF]

open access: yes, 2019
Background: The upper gastrointestinal tract plays a prominent role in human physiology as the primary site for enzymatic digestion and nutrient absorption, immune sampling, and drug uptake.
Bogatyrev, Said R.   +2 more
core   +1 more source

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Fezolinetant is a first‐in‐class, selective, non‐hormonal, neurokinin 3 receptor antagonist that is approved for the treatment of moderate to severe vasomotor symptoms due to menopause. In a phase 2b clinical study (n = 352), nine study participants experienced elevations in serum transaminases exceeding three times the upper limit of normal.
Jace C. Nielsen   +11 more
wiley   +1 more source

Influence of oxidized oils on digestibility of caseins in O/W emulsions [PDF]

open access: yes, 2018
The impact of lipid oxidation on protein modifications in emulsions and the consequences on protein digestibility remains unclear. In this study, this impact is evaluated in casein (6 mg mL(-1)) based emulsions containing oxidized soybean or fish oil (3%)
De Meulenaer, Bruno   +2 more
core   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

open access: yesFood Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi   +4 more
wiley   +1 more source

Adsorption of pancreatic (pro)phospholipase A2 to various physiological substrates.

open access: yesJournal of Lipid Research, 1983
The adsorption of pancreatic phospholipase was studied in vitro in the presence of egg yolk lipoprotein emulsion, Intralipid emulsion, and milk fat globules.
G Nalbone   +9 more
doaj   +1 more source

In vitro antibacterial activity of unconjugated and conjugated bile salts on Staphylococcus aureus [PDF]

open access: yes, 2017
Bile salts are potent antimicrobial agents and are an important component of innate defenses in the intestine, giving protection against invasive organisms.
Acton   +44 more
core   +2 more sources

Chemistry Composition and Bioaccessibility Study of Phenolic Compounds and Carotenoids of New Brazilian Biofortified Sweet Potato “CIP BRS Nuti”

open access: yesFood Chemistry International, EarlyView.
Phenolic compounds of sweet potato CIP BRS Nuti were evaluated for the first time. Catechin, epicatechin, and procyanidin B1 exhibited high bioaccessibility. ABSTRACT Sweet potatoes biofortified in carotenoids have been an alternative to combat malnutrition in vulnerable populations. This work is the first comprehensive study of the bioactive potential
Maria Carla Cândido da Silva   +7 more
wiley   +1 more source

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