Results 61 to 70 of about 29,638 (318)

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat.

Journal of Lipid Research, 1989
Hepatic bile acid synthesis is thought to be under negative feedback control by bile salts in the enterohepatic circulation, acting at the level of cholesterol 7 alpha-hydroxylase (C7 alpha H), the initial and rate-limiting step in the bile acid ...
D M Heuman, P B Hylemon, Z R Vlahcevic
doaj  

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Efficient Exothermic Press toward Ultrafast and Scalable Manufacturing of Complex Polymer Composites

Advanced Science, EarlyView.
Exo‐press frontal polymerization is a rapid, low‐energy process to produce multiscale fiber‐reinforced polymer composites at high fiber volume fractions. By leveraging localized heat, along with a hybrid monomer system, the reaction front cures parts within a minute and forms a copolymer network.
Amirreza Tarafdar, Haining Zhang, Xinlu Wang, Andrea J. Hoe, Kaiyue Deng, Kelvin Fu, Quinn Qiao, Ian D. Hosein, Yeqing Wang   +8 more
wiley   +1 more source

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties[S]

Journal of Lipid Research, 2015
Cytotoxic bile acids, such as deoxycholic acid (DCA), are responsible for hepatocyte cell death during intrahepatic cholestasis. The mechanisms responsible for this effect are unclear, and recent studies conflict, pointing to either a modulation of ...
Tânia Sousa, Rui E. Castro, Sandra N. Pinto, Ana Coutinho, Susana D. Lucas, Rui Moreira, Cecília M.P. Rodrigues, Manuel Prieto, Fábio Fernandes   +8 more
doaj  

Bile Salts Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae

PLoS Neglected Tropical Diseases, 2015
The causative agent of cholera, Vibrio cholerae, regulates its diverse virulence factors to thrive in the human small intestine and environmental reservoirs.
V. Bachmann, Benjamin Kostiuk, Daniel Unterweger, Laura Diaz-Satizabal, S. Ogg, S. Pukatzki   +5 more
semanticscholar   +1 more source

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Receptors

Canadian Journal of Gastroenterology, 2003
The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
doaj   +1 more source

COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells [PDF]

, 2022
Jiangang Shen, Kang Nayoung, Hongfang Wang, Junda Li, Chen Li, Xuefeng Bai, Mingsong Li   +6 more
openalex   +1 more source