Results 1 to 10 of about 67,201 (158)

Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. [PDF]

PLoS ONE, 2013
Bile acids concentration in liver is tightly regulated to prevent cell damage. Previous studies have demonstrated that deregulation of bile acid homeostasis can lead to cholestatic liver disease. Recently, we have shown that ER-bound transcription factor
Dipanjan Chanda, Yong-Hoon Kim, Tiangang Li, Jagannath Misra, Don-Kyu Kim, Jung Ran Kim, Joseph Kwon, Won-Il Jeong, Sung-Hoon Ahn, Tae-Sik Park, Seung-Hoi Koo, John Y L Chiang, Chul-Ho Lee, Hueng-Sik Choi   +13 more
doaj   +3 more sources

Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis

Journal of Lipid Research, 1980
Using thin-layer chromatography, bile alcohol glucuronides were found with taurine- and glycine-conjugated bile acids in the bile of four patients with cerebrotendinous xanthomatosis.
T Hoshita, M Yasuhara, M Une, A Kibe, E Itoga, S Kito, T Kuramoto   +6 more
doaj   +3 more sources

Identification of bile alcohols in rat bile.

Journal of Lipid Research, 1989
Bile alcohols in rat bile were analyzed by gas-liquid chromatography-mass spectrometry. Six bile alcohols were newly identified as minor constituents in addition to 5 beta-cholestane-3 alpha,7 alpha,12 alpha,26-tetrol, major bile alcohol of rat bile. The
T Hiraoka, T Kohda, D Kosaka, T Yamauchi, K Kihira, T Kuramoto, T Hoshita, G Kajiyama   +7 more
doaj   +3 more sources

Ezetimibe Normalizes Dietary Cholesterol-Induced Exacerbation of Liver Injury in Alcohol-Fed Mice [PDF]

Biomolecules
Interactions between alcohol and nutrition play an important role in the development and progression of alcohol-associated liver disease (ALD). Although dietary cholesterol was shown to exacerbate fatty liver and liver injury in alcohol-fed mice ...
Yanchao Xu, Nan Zhang, Piumi B. Wickramasinghe, Kavya Veera, Preethi Parupalli, Alex Dao, Junyu Liu, Rithika Anand, Lyndsey E. Langley, Sreeja Eadha, Hasan Iqbal, Chen Liu, Fang Bian, Lin Jia   +13 more
doaj   +2 more sources

Monitoring Atypical Metabolite Biomarkers in Patients with Bile Acid Synthesis Disorders by a Novel Targeted Tandem Mass Spectrometry Assay [PDF]

Metabolites
Background/Objectives: Bile acid synthesis disorders (BASDs) represent a distinct category of progressive familiar cholestatic liver disease. A novel targeted mass spectrometry assay was developed for the accurate measurement of the major urinary ...
Kenneth D. R. Setchell, Xueheng Zhao, Stacey Reed, Wujuan Zhang   +3 more
doaj   +2 more sources

Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis

JHEP Reports, 2021
Background & Aims: Bile-acid metabolism and the intestinal microbiota are impaired in alcohol-related liver disease. Activation of the bile-acid receptor TGR5 (or GPBAR1) controls both biliary homeostasis and inflammatory processes.
Madeleine Spatz, Dragos Ciocan, Gregory Merlen, Dominique Rainteau, Lydie Humbert, Neuza Gomes-Rochette, Cindy Hugot, Nicolas Trainel, Françoise Mercier-Nomé, Séverine Domenichini, Virginie Puchois, Laura Wrzosek, Gladys Ferrere, Thierry Tordjmann, Gabriel Perlemuter, Anne-Marie Cassard   +15 more
doaj   +1 more source

O-2 CHARACTERIZATION OF SERUM LEVELS OF BILE ACIDS, EXTRACELLULAR VESICLES AND ITS CARGO IN ALCOHOL-ASSOCIATED LIVER DISEASE

Annals of Hepatology, 2023
Introduction and Objectives: Alcohol consumption is among the five main factors responsible for the burden of disease and mortality. It is associated with changes in serum bile acids, and in recent years, extracellular vesicles (EV´s) and their Cargo ...
Jorge Arnold, Luis Antonio Díaz, Francisco Idalsoaga, María Ayala Valverde, Gustavo Ayares, Paula Rivera, Nancy Solís, Marco Arrese, Juan Pablo Arab   +8 more
doaj   +1 more source

Altered metabolism of bile alcohol and bile acid in complete extrahepatic cholestasis: qualitative and quantitative aspects

Journal of Lipid Research, 1987
Urinary excretion of bile alcohols and bile acids in patients with complete extrahepatic cholestasis before and after the release by external biliary drainage was studied.
H Ichimiya, J Yanagisawa, F Nakayama
doaj   +1 more source

A bile alcohol sulfate as a major component in the bile of the small skate (Raja erinacea).

Journal of Lipid Research, 1989
The nature of bile alcohols and bile acids in gall-bladder and hepatic bile from perfused livers of the small skate (Raja erinacea) has been investigated.
G Karlaganis, S E Bradley, J L Boyer, A K Batta, G Salen, B Egestad, J Sjövall   +6 more
doaj   +1 more source

Identification of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25,26-hexol in human urine

Journal of Lipid Research, 1987
A new bile alcohol, 5 beta-cholestanehexol, was identified in the urine of healthy humans as the glucuronide. The bile alcohol glucuronide fraction was isolated by an ion exchange chromatography on piperidinohydroxypropyl Sephadex LH-20.
T Hiraoka, K Kihira, G Kajiyama, T Kuramoto, T Hoshita   +4 more
doaj   +1 more source