Results 71 to 80 of about 881,326 (300)

Preparation of 24(R)- and 24(S)-5β-cholestane-3α,7α,24-triols and 25(R)- and 25(S)-5β-cholestane-3α,7α,26-triols by a hydroboration procedure

Journal of Lipid Research, 1978
This report describes a new and convenient method for the preparation of 5β-cholestane-3α,7α,24-triol (24R and 24S) and 5β-cholestane-3α,7α,26-triol (25R and 25S) starting from 5β-cholestane-3α,7α,25-triol. Dehydration of the latter with acetic anhydride
B Dayal, A K Batta, S Shefer, G S Tint, G Salen, E H Mosbach   +5 more
doaj   +1 more source

Serum bile acids in alcoholics

Kanzo, 1978
大量飲酒者の入院時ならびに治療後の空腹時血清胆汁酸濃度の測定,および血清胆汁酸組成の分析を行つた.検討対象の62例を肝生検によって得た組織所見をもとに,徴少変化群,脂肪肝群,肝線維症群,アルコール性肝炎群,肝硬変症群に分類した.入院時の空腹時血清総胆汁酸濃度は,100μM/l以上の高値を示した2例を含め,62例中51例82%に10μM/l以上の上昇をみた.入院時と治療後の血清胆汁酸濃度の比較では,62例中45例75%に低下がみられ,アルコール性肝炎群の血清胆汁酸濃度の低下は顕著であったが,肝硬変症群は治療後も高値を示す例が多かった.血清胆汁酸組成は,アルコール性肝炎,肝硬変症ではケノデオキシコール酸の組成比増大がみられ,コール酸/ケノデオキシコール酸比は低値を示した ...
MAEYAMA, Toyoaki, ABE, Hirohiko, ANNO, Hiroko, KUWAKI, Toshimitsu, ABE, Masahide, TANIKAWA, Kyuichi, YOKOYAMA, Toshito   +6 more
openaire   +2 more sources

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Regulatory Effect of Daidzein on Lipid and Bile Acid Metabolism Disorders in Alcoholic Liver Disease via the Gut-Liver Axis [PDF]

Shipin Kexue
This study explored the ameliorative effect of daidzein (DAI) on alcoholic liver disease (ALD) in rats and examined the underlying mechanism using transcriptomics and high-throughput 16S rRNA sequencing.
WANG Qiannan, TONG Jian, LIU Shuang, SHI Jialing, LI Tianhao, CHEN Mengmeng, WANG Heyu, BI Yunfeng
doaj   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Alcohol-induced gut microbiome dysbiosis enhances the colonization of Klebsiella pneumoniae on the mouse intestinal tract

mSystems
Chronic alcohol consumption, an important risk factor for diseases and deaths, can cause intestinal microbiota dysbiosis and increase the infection of some opportunistic pathogens. However, the current studies on the effects of alcohol-induced intestinal
Mengke Shen, Huajie Zhao, Meiqing Han, Lin Su, Xiaojian Cui, Duan Li, Liang Liu, Chuansheng Wang, Fan Yang   +8 more
doaj   +1 more source

Conditions for solid-phase extraction of urinary bile acids with octadecylsilane-bonded silica

Journal of Lipid Research, 1994
Fast atom bombardment mass spectrometry was used as a detection method in a study of the extraction of urinary bile acids with octadecylsilane-bonded silica.
E Wahlén, N Tamasawa, H Ichimiya, B Egestad, J Sjövall   +4 more
doaj   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source