Results 161 to 170 of about 399,922 (291)

A Versatile Microfluidic Manufacturing Platform for Macroscale Multicore Hydrogel Capsules Toward Programmable Oral Delivery of Therapeutics

Small, EarlyView.
This study presents a microfluidic fabrication method for millimeter‐scale multicore hydrogel capsules containing multiple aqueous cores physically isolated by oil layers. These macrocapsules exhibit mechanical and chemical robustness effectively protecting cargos under simulated gastric conditions.
Hye‐Seon Jeong, Chae‐Hee Park, Yoon Choi, Hyunmin Yi, Chang‐Hyung Choi   +4 more
wiley   +1 more source

Metabolism of bile salts in the estrogen degrading bacterium Caenibius tardaugens. [PDF]

Biodegradation
Ibero J, Hernández-Fernández G, García JL, Galán B.   +3 more
europepmc   +1 more source

Highly Hydrophilic and Lipophilic Derivatives of Bile Salts. [PDF]

Int J Mol Sci, 2021
Vázquez-Tato MP, Seijas JA, Meijide F, Fraga F, de Frutos S, Miragaya J, Trillo JV, Jover A, Soto VH, Vázquez Tato J.   +9 more
europepmc   +1 more source

Reverse Micelles: The Gateway for Oral (Poly)Peptide Delivery

Small, EarlyView.
RM achieve superior oral peptide delivery through high loading capacity, strong lipophilicity, and a low‐hydration microenvironment that protects against enzymatic degradation. Meanwhile, dRM provides favorable permeation‐enhancing interactions and a consistent safety profile, collectively driving enhanced oral performance.
Marlene Ramona Schmidt, Melanie Lena Ebert, Andreas Bernkop‐Schnürch   +2 more
wiley   +1 more source

Cholesterol attenuates cytoprotective effects of phosphatidylcholine against bile salts. [PDF]

Bile salts have potent detergent properties and damaging effects on cell membranes, leading to liver injury. However, the molecular mechanisms for the protection of hepatocytes against bile salts are not fully understood.
森田, 真也, 0000-0003-4079-707X, 7156, 4010, 675, 40736980, 10324641, TERADA, Tomohiro, 池田, 義人, 20449870, 寺田, 智祐, IKEDA, Yoshito   +11 more
core  

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source

Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? [PDF]

World J Gastroenterol
Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB.   +4 more
europepmc   +1 more source

Comparison of the Performance of Different Bile Salts in Enantioselective Separation of Palonosetron Stereoisomers by Micellar Electrokinetic Chromatography. [PDF]

Molecules, 2022
Hu S, Sun T, Li R, Zhang D, Zhang Y, Yang Z, Feng G, Guo X.   +7 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition. [PDF]

Redox Biol
Chen L, Ballout F, Chen Z, Thangaretnam K, Que J, Chen XS, McDonald OG, Zaika A, Livingstone A, Giordano S, Shiekhattar R, Lu H, Peng D, El-Rifai W.   +13 more
europepmc   +1 more source