Results 171 to 180 of about 45,839 (288)

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Growth of Bifidobacterium species is inhibited by free fatty acids and bile salts but not by glycerides. [PDF]

AIMS Microbiol, 2022
Perez-Burillo S, Rajakaruna S, Paliy O.
europepmc   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Metabolism of bile salts in the estrogen degrading bacterium Caenibius tardaugens. [PDF]

Biodegradation
Ibero J, Hernández-Fernández G, García JL, Galán B.   +3 more
europepmc   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Highly Hydrophilic and Lipophilic Derivatives of Bile Salts. [PDF]

Int J Mol Sci, 2021
Vázquez-Tato MP, Seijas JA, Meijide F, Fraga F, de Frutos S, Miragaya J, Trillo JV, Jover A, Soto VH, Vázquez Tato J.   +9 more
europepmc   +1 more source

Impact of Biologically Relevant Bile Salts on Solution Crystallization

, 2017
With the increasing number of poorly soluble compound in the drug developmental pipeline, a variety of formulation strategies have been developed to address this issue.
Lu, Jennifer
core  

Neuregulin 4‐dependent MAPK amplification mediates urate‐induced β‐cell dysfunction

Journal of Diabetes Investigation, EarlyView.
Hyperuricemia impairs glucose homeostasis by inducing pancreatic β‐cell apoptosis without insulin resistance. In male Uox‐KO mice, urate upregulates Nrg4, which amplifies MAPK signaling and drives β‐cell death. Thus, hyperuricemia disrupts glucose metabolism via the Nrg4‐MAPK axis.
Yunyang Wang, Kun Zhang, Zhiyuan Li, Shuhui Hu, Yiru Zhang, Yulei Zhao, Xiaohan Liu, Jie Lu   +7 more
wiley   +1 more source

Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? [PDF]

World J Gastroenterol
Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB.   +4 more
europepmc   +1 more source

Comparison of the Performance of Different Bile Salts in Enantioselective Separation of Palonosetron Stereoisomers by Micellar Electrokinetic Chromatography. [PDF]

Molecules, 2022
Hu S, Sun T, Li R, Zhang D, Zhang Y, Yang Z, Feng G, Guo X.   +7 more
europepmc   +1 more source