Results 91 to 100 of about 258,858 (308)

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

On Infrared Absorption Spectra of Bilirubin and Calcium Bilirubinate

The Tohoku Journal of Experimental Medicine, 1966
This paper deals with the infrared absorption spectra of bilirubin and calcium bilirubinate in order to provide a better understanding in the analysis of gallstones by means of infrared spectroscopy. The infrared spectra of these two authentic compounds, together with powdered pigmented calcium stones and their fractions, have been measured for the ...
Suzuki, Noriyoshi, Toyoda, Masayuki
openaire   +3 more sources

Total serum bilirubin and transcutaneous bilirubin levels.

, 2019
Total serum bilirubin and transcutaneous bilirubin levels.
Arend F. Bos (415872), Christian V. Hulzebos (410310), Deirdre E. Vader-van Imhoff (6843380), Peter H. Dijk (410312)   +3 more
core   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor

Frontiers in Immunology, 2018
Background & aimsKnowledge about innate antimicrobial defense of the liver is limited. We investigated hepatic expression and regulation of antimicrobial peptides with focus on the human beta defensin-1 (hBD-1).MethodsRadial diffusion assay was used ...
Thomas Klag, Maria Thomas, Dirk Ehmann, Lioba Courth, Daniela Mailänder-Sanchez, Thomas S. Weiss, Rania Dayoub, Kerstin Abshagen, Brigitte Vollmar, Wolfgang E. Thasler, Eduard F. Stange, Christoph P. Berg, Nisar P. Malek, Ulrich M. Zanger, Jan Wehkamp   +14 more
doaj   +1 more source

The impact of bilirubin ditaurate on platelet quality during storage

, 2019
Bilirubin ditaurate (BRT), a conjugated bilirubin analogue, has demonstrated anti-platelet characteristics following acute ex vivo exposure. Scavenging of mitochondrial superoxide and attenuation of granule exocytosis suggested a potential benefit for ...
Karl-Heinz Wagner, Evan Noel Pennell, Josif Vidimce, Shibeeb, Sapha, Wagner, Karl-Heinz, Andrew Cameron Bulmer, Vidimce, Josif, Sapha Shibeeb, Pennell, Evan Noel, Shiels, Ryan, Bulmer, Andrew Cameron, Ryan Shiels   +11 more
core   +1 more source

Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.

, 2020
BACKGROUND: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating ...
Stepien, Magdalena, Carreras-Torres, Robert, Banbury, Barbara L, Bueno-de-Mesquita, Bas, Tjønneland, Anne, Jenab, Mazda, Murphy, Neil, Aleksandrova, Krasimira, Seyed Khoei, Nazlisadat, Viallon, Vivian, Weiderpass, Elisabete, Cross, Amanda J, Bulmer, Andrew, Kühn, Tilman, et al.   +14 more
core   +1 more source