Results 81 to 90 of about 215,346 (265)

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor

Frontiers in Immunology, 2018
Background & aimsKnowledge about innate antimicrobial defense of the liver is limited. We investigated hepatic expression and regulation of antimicrobial peptides with focus on the human beta defensin-1 (hBD-1).MethodsRadial diffusion assay was used ...
Thomas Klag, Maria Thomas, Dirk Ehmann, Lioba Courth, Daniela Mailänder-Sanchez, Thomas S. Weiss, Rania Dayoub, Kerstin Abshagen, Brigitte Vollmar, Wolfgang E. Thasler, Eduard F. Stange, Christoph P. Berg, Nisar P. Malek, Ulrich M. Zanger, Jan Wehkamp   +14 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

Angewandte Chemie, EarlyView.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang, Jingqu Chen, Siying Chen, Binsha Peng, Zhifeng Zhou, Ling Zhang, Rui Xie, Xiaojie Ju, Wei Wang, Dawei Pan, Liangyin Chu, Frank Caruso, Zhuang Liu   +12 more
wiley   +2 more sources