Results 81 to 90 of about 258,858 (308)

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

open access: yesAdvanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang   +10 more
wiley   +1 more source

Serum bilirubin and lipoprotein-a: How are these associated with whole blood viscosity?

open access: yes, 2012
Background It has been demonstrated that oxidative stress can induce red blood cell rigidity and haemolysis, which in turn can cause hyperviscosity and hyperbilirubinaemia, respectively.
Bwititi, P.   +3 more
core   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

open access: yesAdvanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen   +7 more
wiley   +1 more source

Direct Bilirubin Higher Than Total Bilirubin?

open access: yesClinical Chemistry, 2015
A 77-year-old man with multiple myeloma and recent cholecystostomy tube placement presented to the emergency department with pneumonia. His cholecystostomy tube was noted to be clamped shut. Total and direct serum bilirubin measurements were 0.2 and 1.66 mg/dL, respectively. Dilutions of the specimen were made, and the results …
Matthew, Ball   +2 more
openaire   +2 more sources

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

open access: yesAdvanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang   +8 more
wiley   +1 more source

Inherited disorders of bilirubin clearance [PDF]

open access: yes, 2015
Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii ...
Barry I Weinberger   +7 more
core   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

open access: yesAdvanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo   +15 more
wiley   +1 more source

Morphology and composition of gallstones in 90 cholecystectomys performed at the Hospital Universitario del Caribe. 2008 -2009

open access: yesRevista Ciencias Biomédicas, 2010
The biliary lithiasis is a major problem in Western health systems; many studies have identified several risk factors including increased cholesterol saturation, which is why most of the gallstones can be dissolved with bile salts, but this constitutes a
Colpas-Morales Liceloth Sofía   +3 more
doaj  

Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo

open access: yesFrontiers in Neurology, 2020
Objective: To investigate the roles of serum uric acid (UA), bilirubin (BIL), albumin (ALB), and creatinine (CRE) as major intravascular antioxidants, in benign paroxysmal positional vertigo (BPPV).Methods: The serum levels of UA, BIL, ALB, and CRE were ...
Ke-Hang Xie   +9 more
doaj   +1 more source

Mirror covered tunnel phototherapy increases the efficacy of phototherapy for neonatal jaundice [PDF]

open access: yes
Objective: Neonatal jaundice (NJ) is one of the most common cause of neonatal hospital admission. Phototherapy is the main therapy for hyperbilirubinemia of neonatal jaundice. The efficacy of phototherapy depends on the dose and wavelength of light used
امینی ثانی, نیره   +6 more
core  

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