Results 71 to 80 of about 282,772 (364)

Splenomegaly in predicting the survival of patients with advanced primary liver cancer treated with immune checkpoint inhibitors

Cancer Medicine, Volume 11, Issue 24, Page 4880-4888, December 2022., 2022
Kaplan–Meier analysis demonstrated that patients with splenomegaly had worse OS than those without splenomegaly. Abstract Background & aims Immune checkpoint inhibitors (ICIs) play an increasingly important role in the treatment of primary liver cancer (PLC). Some patients with PLC experience symptoms of splenomegaly.
Lu‐Shan Xiao, Cheng‐Yi Hu, Hao Cui, Rui‐Ning Li, Chang Hong, Qi‐Mei Li, Chao‐Yi Huang, Zhong‐Yi Dong, Hong‐Bo Zhu, Li Liu   +9 more
wiley   +1 more source

Bilirubin-liposome interaction. Binding of bilirubin dianion, protonization, and aggregation of bilirubin acid. [PDF]

Journal of Biological Chemistry, 1981
Interaction of bilirubin with phospholipid liposomes was studied at varying pH. Liposomes were prepared from egg-phosphatidylcholine, dipalmitoyl-phosphatidylcholine, phosphatidylethanolamine, egg-phosphatidylcholine, and phosphatidylethanolamine with 5% (w/w) cholesterol, phosphatidylserine, sphingomyelin, and a lipid preparation from cat brain ...
E F Eriksen, H Danielsen, R Brodersen
openaire   +2 more sources

Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone

Advanced Therapeutics, Volume 8, Issue 5, May 2025.
Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe, Jena E. Moseman, Jamie M. Jones, Jacobus C. Burger, Ashley M. Weichmann, Douglas G. McNeel, William L. Murphy   +6 more
wiley   +1 more source

On detecting reference level of acrolein content in children's blood

Analiz Riska Zdorovʹû, 2017
The article gives the results of complex chemical-analytical and clinical-laboratory research in course of which biological media of children living in Perm region were examined.
T.S. Ulanova, O.O. Sinitsyna, T.D. Karnazhitskaya, E.O. Zavernenkova   +3 more
doaj   +1 more source

Application of the ALBI Scoring System for Mortality Outcome Prediction in Patients with Hypertrophic Cardiomyopathy

Global Heart, 2022
Background: There is no information about the clinical significance of the albumin-bilirubin (ALBI) score in patients with hypertrophic cardiomyopathy (HCM).
Ping Qiao, Liying Li, Haiyan Ruan, Muxin Zhang, Ziqiong Wang, Xinran Li, Rufeng Shi, Xin Wei, Linjia Duan, Yi Zheng, Sen He   +10 more
doaj   +1 more source

Arterial blood pressure waveform in liver transplant surgery possesses variability of morphology reflecting recipients' acuity and predicting short term outcomes [PDF]

arXiv, 2021
Background: We investigated clinical information underneath the beat-to-beat fluctuation of the arterial blood pressure (ABP) waveform morphology. We proposed the Dynamical Diffusion Map algorithm (DDMap) to quantify the variability of morphology. The underlying physiology could be the compensatory mechanisms involving complex interactions between ...
arxiv  

Bilirubin and Endothelial Function

Journal of atherosclerosis and thrombosis, 2019
Bilirubin is a fundamental metabolic end product of heme degradation. Despite acting as a cytotoxic metabolite at high concentrations, bilirubin at physiological concentrations has antioxidant effects, such as scavenging reactive oxygen species, leading ...
T. Maruhashi, Y. Kihara, Y. Higashi
semanticscholar   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis

Cell Biology International, Volume 47, Issue 2, Page 467-479, February 2023., 2023
Abstract Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common
Amy L. Lightner, Neda Dadgar, Anil Vaidya, Robert Simon, Clifton Fulmer, Hassan Siddiki, K. V. Narayanan Menon, Peter Liu, R. Matthew Walsh   +8 more
wiley   +1 more source

The jaundiced newborn: which early monitoring for a safe discharge?

La Pediatria Medica e Chirurgica, 2013
Neonatal jaundice is one of the most common causes of prolonged hospital stay or readmission of a near-term or term baby. Reason of concern at early discharge of a jaundiced newborn is that of bilirubin neurotoxicity, even if a serum bilirubin ...
S. Pratesi, C. Dani
doaj   +1 more source